Supplement
Restores low vitamin D status and supports calcium handling pathways with vitamin K2.[2109,2184,2604, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
9
Mixed / Neutral • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 17 • links 53
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Immune Support, Bone Health, Hormone Health.[206,218,241, etc.]
Dose guide: D3 1000-4000 IU/day; K2 MK-7 90-180 mcg/day.[206,218,241, etc.]
Category
Vitamin
Evidence Tier
HIGH
Daily Guide
D3 1000-4000 IU/day; K2 MK-7 90-180 mcg/day
Clinical Depth
Humans: 2,830 • RCTs: 1,037 • Meta: 80
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 752 • Interactions: 1,063
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
4283 total studies · 8 recent
Timeline
Total indexed
4,283
Animal-only studies
4,167
Human studies
2,830
In vitro / tissue
2,296
Interaction signals
1,063
Randomized trials
1,037
Weighted direction score: 9 (Mixed / Neutral)
Aggregated evidence from 3 mapped records: Vitamin D3, Vitamin K1, Vitamin K2.
Total indexed
4,283
Animal-only studies
4,167
Human studies
2,830
In vitro / tissue
2,296
Interaction signals
1,063
Randomized trials
1,037
Safety adverse signals
752
Meta-analyses
80
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 22552031 • 2012 Jun
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis.
Am J Clin Nutr
Open PubMedPMID 39421966 • 2024 Dec
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
Ann Med
Open PubMedPMID 37865222 • 2024 Jan
Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.
Adv Nutr
Open PubMedPMID 35842938 • 2023 Jan
What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
Int J Older People Nurs
Open PubMedPMID 36744416 • 2023 Feb 6
Vitamin D for the management of asthma.
Cochrane Database Syst Rev
Open PubMedPMID 30556597 • 2018 Dec 17
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Cochrane Database Syst Rev
Open PubMedPMID 40409468 • 2025 Jul
Vitamin D(3) and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 31454046 • 2019 Aug 27
Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial.
JAMA
Open PubMedPMID 33865361 • 2021 Apr 17
The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial.
BMC Pediatr
Open PubMedPMID 36441522 • 2023 Jan 1
Influence of Vitamin D Supplementation on Growth, Body Composition, and Pubertal Development Among School-aged Children in an Area With a High Prevalence of Vitamin D Deficiency: A Randomized Clinical Trial.
JAMA Pediatr
Open PubMedPMID 33170239 • 2020 Nov 10
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.
JAMA
Open PubMedPMID 32840597 • 2020 Aug 25
Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.
JAMA
Open PubMedPMID 38828931 • 2024 Jul 12
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline.
J Clin Endocrinol Metab
Open PubMedPMID 32487800 • 2020 Oct
Vitamin D supplementation during pregnancy: an overview.
Curr Opin Obstet Gynecol
Open PubMedPMID 26962786 • 2016 Mar
Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True?: A Systematic Review.
Medicine (Baltimore)
Open PubMedPMID 28445289 • 2017 Apr
Vitamin K intake and the risk of fractures: A meta-analysis.
Medicine (Baltimore)
Open PubMedPMID 38282652 • 2024
The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis.
J Nutr Sci
Open PubMedPMID 38652023 • 2024 Apr
Serum vitamins and homocysteine levels in autoimmune liver disease: A systematic review and meta-analysis.
Immun Inflamm Dis
Open PubMedPMID 34649591 • 2021 Oct 14
The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials.
J Orthop Surg Res
Open PubMedPMID 41599883 • 2026 Jan 14
The Differential Effects of Vitamin K Across Glycaemic Outcomes in Prediabetes and Type 2 Diabetes Mellitus.
Nutrients
Open PubMedPMID 23525894 • 2013 Sep
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
Osteoporos Int
Open PubMedPMID 36460034 • 2023 Sep 29
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial.
Nephrol Dial Transplant
Open PubMedPMID 39680321 • 2025 Mar
Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial.
J Nephrol
Open PubMedPMID 34960106 • 2021 Dec 20
Fat-Soluble Vitamin Supplementation Using Liposomes, Cyclodextrins, or Medium-Chain Triglycerides in Cystic Fibrosis: A Randomized Controlled Trial.
Nutrients
Open PubMedBenefit reports: 8
Adverse reports: 5
No-effect reports: 1
Mixed reports: 3
Unclear reports: 0
Signal confidence: 0.34
Benefits
Adverse
No Effect
Strong preference for softgels with oil base. | Step2: Aggregated empirical signal from 3 mapped records.
Reddit evidence: 14 mentions (confidence 0.34) across Supplements, nutrition, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use. | Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use. | Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
ODS fact sheet linked for safety review.
Imported legacy community score: 10.0/10 (manual mapping confidence 1.00).
Imported legacy monthly cost signal: ~$8.00.
Legacy community note: The most universally recommended supplement across all health communities. Users frequently report improved energy, mood, and reduced illness frequency. Consistently called "the one supplement everyone should take."
Sentiment Score
0.24044799999999997/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
post • r/Supplements • unclear
Do I Really Need to Supplement MK-7 With Vitamin D3? So, my doctor says that I don’t need MK-7 since I don’t have any bone problems, and that calcification is only an issue when the serum level exceeds 150 ng/ml. But on the internet, I rea…
Open mentionpost • r/Supplements • unclear
I want to supplement with 5,000 IU of vitamin D3 and this supplement has it and more ingredient Is Magnesium Citrate 120mg enough to replenish what vitamin D3 use and since it also has Boron and Zinc what other supplement do I need to take…
Open mentionpost • r/Supplements • unclear
Whats a good supplement for Vitamin D3 and K2? I am looking to start supplementing Vitamin D3 and from what I have read you should take it alongside K2 so what are some brands that are reputable/safe that have them both? I would prefer for…
Open mentionpost • r/Supplements • benefit
Vitamin D3 Supplements Caused Strange Symptoms Hello, I took 2000IU Vitamin D3 for about a month. About a week ago I decided to stop because I had increased sebum or oily skin, increased body odor, and an itchy face and scalp. Since being …
Open mentionpost • r/Supplements • adverse
Vitamin D3 side effects Is it normal to feel extreme anxiety, depression and panic attacks after supplementing 3000IU of D3? It says the recommended intake is 2000IU but I’ve heard people say 5000IU is okay so I ate 3 gummies instead of 2.…
Open mentionpost • r/nutrition • unclear
Should vitamin D3 supplements be taken with K2? If so, which is a good brand? How much should adults in Canada be taking? How much for kids? I am familiar with the vitamin d recommendations but not K2.
Open mentionpost • r/Supplements • benefit
Which is the better Vitamin D3 + K2 Supplement? I’m looking for a 5,000 IU D3 supplement as I’m deficient in Vitamin D (actually below deficient levels). My doctor prescribed a 50,000 IU supplement once per week for 12 weeks. I’m scared to…
Open mentionpost • r/Biohackers • unclear
What vitamin D3 dosage is best/optimal for everyday health and fitness 27M in US east coast. I don’t spend much time directly in the sun, only near windows.
Open mentioncomment • r/Supplements • unclear
telling you this from personal experience not just the science, ALWAYS TKAE MK7 WITH IT, especially if you have higher dosages daily or monthly, that calcium could POTENTIALLY build up elsewhere!! my sister literally started becoming so di…
Open mentioncomment • r/Supplements • unclear
Do you have any links to studies showing that vitamin D3 supplementation burns through magnesium and consequently requires extra supplemental magnesium? If so, would you mind sharing? Thank you!
Open mentionpost • r/Supplements • no_effect
Vitamin K1 - Caused depression? I've had a condition called CSR in both eyes for a little over 4 months. As my doctor told me there's basically nothing to do, other than wait it out, i've been experimenting with some supplements. First, i …
Open mentionpost • r/Supplements • unclear
Vitamin K1 and risk of bleeding Does anyone know if vitamin K1 will make your blood too thin and thus make you bleed and bruise too easily? I have a connective tissue disorder, which means we already have thin skin that bruises and bleeds …
Open mentionpost • r/Supplements • mixed
Going down the K2 rabbit hole — does it actually do anything? Body of literature is based on fraud? MK-7 is not effectively metabolized by the body compared to MK-4 or is it the other way around? Trying to understand this for a relative wh…
Open mentionpost • r/Biohackers • unclear
What is the proper dose of Vitamin K1 to match 50000 IU of vitamin D3? I mean, to counteract the calcium leeching effect of high vitamin d dose. I am about taking 50000 IU (per week) after my meal. I bought the vitamin K1 supplement, not k…
Open mentionpost • r/Supplements • unclear
I've compared 6 most premium multivitamin ingredients in single table for nerds I was trying to compare them and do some ChatGPT work for you and here is the complete context for nerds for top selling tier-1 vitamins compared per serving v…
Open mentioncomment • r/Supplements • adverse
There are cofactors for every nutrient. Especially if the cofactors are low, will it cause symptoms if another cofactor amount is adjusted. Vitamin K1 operates with vitamin D and magnesium. You need to adjust all cofactors upwards in propo…
Open mentionamazon
Amazon search for Vitamin D3 + K2
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
COHORT • 2022 • Adults
Associational evidence across populations.
Outcome: Low status linked with worse outcomes.[2109,2184,2604, etc.]
RCT • 2020 • Adults
Mixed baseline status cohorts.
Outcome: Benefits strongest in deficiency and older adults.[2109,2184,2604, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 2830, RCTs 1037, meta-analyses 80.[2109,2184,2604, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22552031 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39421966 from Ann Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37865222 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35842938 from Int J Older People Nurs.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36744416 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30556597 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40409468 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31454046 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33865361 from BMC Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36441522 from JAMA Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33170239 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32840597 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38828931 from J Clin Endocrinol Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32487800 from Curr Opin Obstet Gynecol.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26962786 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28445289 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38282652 from J Nutr Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38652023 from Immun Inflamm Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34649591 from J Orthop Surg Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41599883 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23525894 from Osteoporos Int.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36460034 from Nephrol Dial Transplant.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39680321 from J Nephrol.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34960106 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2109,2184,2604, etc.]
Open source