Supplement
Lignans bind SHBG (increasing free testosterone), inhibit 5α-reductase and aromatase, lectins activate T cells, and flavonoids provide anti-inflammatory / antihistamine activity.[1355,1568,1578, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
0/100
Sparse depth from human/RCT/meta counts
Community Direction
9
Mixed / Neutral • confidence Low
Safety Friction
11/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 8 • mentions 8 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Hormone Health, Joint Health, Inflammation.[207,249,1016, etc.]
Dose guide: 300-600 mg root extract daily (standardized), or 300-500 mg leaf extract.[207,249,1016, etc.]
Category
Botanical
Evidence Tier
EXPLORATORY
Daily Guide
300-600 mg root extract daily (standardized), or 300-500 mg leaf extract
Clinical Depth
Humans: 0 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 0 • Interactions: 1
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
0 total studies · 1 recent
Timeline
Animal-only studies
3
In vitro / tissue
2
Interaction signals
1
Total indexed
0
Human studies
0
Randomized trials
0
Weighted direction score: 9 (Mixed / Neutral)
Mostly preclinical / in-vitro or sparse human literature.
Animal-only studies
3
In vitro / tissue
2
Interaction signals
1
Total indexed
0
Human studies
0
Randomized trials
0
Meta-analyses
0
Safety adverse signals
0
Distribution of evidence by study design strength
PMID 15045190 • 2004 Mar
[Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months].
Der Urologe. Ausg. A
Open PubMedPMID 35900970 • 2022
Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist-Implications for male fertility.
PloS one
Open PubMedPMID 7510891 • 1994 Feb
Effects of stinging nettle root extracts and their steroidal components on the Na+,K(+)-ATPase of the benign prostatic hyperplasia.
Planta medica
Open PubMedPMID 10705733 • 2000 Feb
Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract.
Planta medica
Open PubMedPMID 31852737 • 2020 Jan 31
Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
The Journal of biological chemistry
Open PubMedPMID 38560358 • 2024
Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS(®) 1541) on prostate hyperplasia and inflammation in rats and human cells.
Frontiers in pharmacology
Open PubMedPMID 9270373 • 1997 Aug
The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse.
Planta medica
Open PubMedPMID 14716106 • 2003 Winter
Effects of Nigella sativa L. and Urtica dioica L. on selected mineral status and hematological values in CCl4-treated rats.
Biological trace element research
Open PubMedBenefit reports: 4
Adverse reports: 3
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.13
Benefits
Adverse
No Effect
Distinct uses: root for prostate/hormones, leaf for allergies/inflammation. Often combined with saw palmetto for prostate health.
Reddit evidence: 1 mentions (confidence 0.13) across Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 9 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Sentiment Score
0.55/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
post • r/Supplements • mixed
Looking for the Best Supplements for Weak Urine Flow, Dribbling, Weak Ejaculation & Erectile Issues Hey everyone, I’m a male in my 30s and I’ve been experiencing a few issues that I’m hoping to improve naturally through supplements. Specif…
Open mentionpost • r/Supplements • unclear
Stinging Nettle root There is conflicting info on whether it raises or reduces DHT ? I know its recommended for Prostate health but I was thinking of taking it for its anti inflammatory and mild 5 ar inhibitory effects Is it worth taking ?…
Open mentionamazon
Amazon search for Stinging Nettle Root (Urtica dioica)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
META_ANALYSIS • 2019 • Adults
6 RCTs with 558 men with BPH.
Outcome: Nettle root significantly improved IPSS urinary symptom scores, peak flow rate, and residual volume in benign prostatic hyperplasia.[1355,1568,1578, etc.]
Open sourceRCT • 2009 • Adults
81 patients with knee or hip OA.
Outcome: Nettle extract significantly reduced NSAID requirement (−58%) while maintaining pain control; prostaglandin inhibition mechanism.[1355,1568,1578, etc.]
Open sourceRCT • 2014 • Adults
60 men with BPH.
Outcome: Nettle root 300 mg TID significantly increased free testosterone by inhibiting SHBG binding and reduced DHT; improved urinary symptoms.[1355,1568,1578, etc.]
Open sourcePUBMED • 2004 • Human evidence curation set
PMID 15045190 from Der Urologe. Ausg. A.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35900970 from PloS one.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 1994 • Human evidence curation set
PMID 7510891 from Planta medica.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 2000 • Human evidence curation set
PMID 10705733 from Planta medica.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31852737 from The Journal of biological chemistry.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38560358 from Frontiers in pharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 1997 • Human evidence curation set
PMID 9270373 from Planta medica.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 14716106 from Biological trace element research.
Outcome: See linked PubMed abstract for methods and outcomes.[1355,1568,1578, etc.]
Open source