Supplement
Supports broad cellular function with category-specific mechanisms.[2721,2827,2830, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
33
Positive Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 3 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[576,724,948, etc.]
Dose guide: Human-study daily dose: 1 mg-4000 mg/day (higher-confidence extraction from PubMed abstracts)..[576,724,948, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 1 mg-4000 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 318 • RCTs: 66 • Meta: 29
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 229 • Interactions: 633
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
815 total studies · 6 recent
Timeline
Animal-only studies
2,730
Total indexed
815
In vitro / tissue
771
Interaction signals
633
Human studies
318
Safety adverse signals
229
Weighted direction score: 33 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
2,730
Total indexed
815
In vitro / tissue
771
Interaction signals
633
Human studies
318
Safety adverse signals
229
Randomized trials
66
Meta-analyses
29
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39019217 • 2024 Aug
Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
Adv Nutr
Open PubMedPMID 39698034 • 2024
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
Front Endocrinol (Lausanne)
Open PubMedPMID 36790138 • 2023 Feb 15
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.
Cochrane Database Syst Rev
Open PubMedPMID 32851663 • 2020 Aug 27
Antioxidants for female subfertility.
Cochrane Database Syst Rev
Open PubMedPMID 35889788 • 2022 Jul 9
Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nutrients
Open PubMedPMID 28752910 • 2017 Jul 28
Antioxidants for female subfertility.
Cochrane Database Syst Rev
Open PubMedPMID 28724185 • 2017 Jun
Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto's patients with subclinical hypothyroidism.
Eur Rev Med Pharmacol Sci
Open PubMedPMID 38051700 • 2023 Dec
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial.
PLoS Med
Open PubMedPMID 40920401 • 2025 Oct 7
Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.
JAMA
Open PubMedPMID 39141124 • 2024 Oct
Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial.
Arch Gynecol Obstet
Open PubMedPMID 27910708 • 2017 Apr
Myo-inositol and melatonin in the menopausal transition.
Gynecol Endocrinol
Open PubMedPMID 39781581 • 2025 Apr
Efficacy of myo-inositol and zinc on insulin resistance in a paediatric population with obesity.
Diabetes Obes Metab
Open PubMedPMID 35057707 • 2022 Aug
D-Chiro-inositol and PCOS: between myth and reality. The never-ending story.
Int J Food Sci Nutr
Open PubMedPMID 38184959 • 2024 Mar
Nutritional supplements and IVF: an evidence-based approach.
Reprod Biomed Online
Open PubMedPMID 32396844 • 2020 Jun
Inositols in Polycystic Ovary Syndrome: An Overview on the Advances.
Trends Endocrinol Metab
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22myo-inositol%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22myo-inositol%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=myo-inositol
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 1 mg-4000 mg/day (confidence HIGH).
Extracted from 11 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Legacy community note: Extremely popular in PCOS and anxiety communities. Women with PCOS report dramatic improvements in cycles, acne, and bloodwork. Anxiety users praise its calming effect without sedation. 40:1 myo-inositol to D-chiro-inositol ratio recommended for PCOS.
Sentiment Score
-0.3/100
Benefit Mentions
No benefit mentions recorded.
Adverse Mentions
No adverse mentions recorded.
Best Responders
No responder profile recorded.
aggregate • benefit
Aggregate community signal: 3 directional mentions (benefit 2, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Myo-inositol
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 318, RCTs 66, meta-analyses 29.[2721,2827,2830, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39019217 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39698034 from Front Endocrinol (Lausanne).
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36790138 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32851663 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35889788 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28752910 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28724185 from Eur Rev Med Pharmacol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38051700 from PLoS Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40920401 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39141124 from Arch Gynecol Obstet.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27910708 from Gynecol Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39781581 from Diabetes Obes Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35057707 from Int J Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38184959 from Reprod Biomed Online.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32396844 from Trends Endocrinol Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2721,2827,2830, etc.]
Open source