Supplement
Contains 3-6% natural L-DOPA (dopamine precursor), reduces cortisol, increases testosterone and LH, provides antioxidant protection for dopaminergic neurons, and modulates prolactin.[1897,1918,1993, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
52/100
Moderate depth from human/RCT/meta counts
Community Direction
-9
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 10 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Mood, Hormone Health, Libido, Stress Resilience.[574,722,946, etc.]
Dose guide: Human-study daily dose: 10 mg-200 mg/day (higher-confidence extraction from PubMed abstracts)..[574,722,946, etc.]
Category
Botanical
Evidence Tier
EMERGING
Daily Guide
Human-study daily dose: 10 mg-200 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 12 • RCTs: 3 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 43 • Interactions: 16
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
62 total studies · 4 recent
Timeline
Animal-only studies
113
Total indexed
62
In vitro / tissue
56
Safety adverse signals
43
Interaction signals
16
Human studies
12
Weighted direction score: -9 (Mixed / Neutral)
Some human evidence or substantial animal evidence.
Animal-only studies
113
Total indexed
62
In vitro / tissue
56
Safety adverse signals
43
Interaction signals
16
Human studies
12
Randomized trials
3
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 28679598 • 2017 Aug 1
Mucuna pruriens in Parkinson disease: A double-blind, randomized, controlled, crossover study.
Neurology
Open PubMedPMID 41269916 • 2026 Feb
Mucuna pruriens in untreated Parkinson's disease in sub-Saharan Africa: A 12-month, multicenter, randomized, controlled trial.
Journal of Parkinson's disease
Open PubMedPMID 29352722 • 2018 Apr
Daily intake of Mucuna pruriens in advanced Parkinson's disease: A 16-week, noninferiority, randomized, crossover, pilot study.
Parkinsonism & related disorders
Open PubMedPMID 35939305 • 2022 Oct 1
Levodopa Content of Mucuna pruriens Supplements in the NIH Dietary Supplement Label Database.
JAMA neurology
Open PubMedPMID 38462520 • 2024 Oct 15
Japanese Mucuna pruriens (Hasshou Beans) Showed Fast-acting and Long-lasting Effects in Parkinson's Disease.
Internal medicine (Tokyo, Japan)
Open PubMedPMID 41575577 • 2026 Jan 23
Analysis of amino acids in Mucuna pruriens supplements using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Amino acids
Open PubMedPMID 32179240 • 2020 Apr
Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?
Parkinsonism & related disorders
Open PubMedPMID 31796973 • 2019 Dec
Dietary Supplement Use is High among Individuals with Parkinson Disease.
Southern medical journal
Open PubMedPMID 29427634 • 2018 May 10
Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling.
Journal of ethnopharmacology
Open PubMedPMID 26366963 • 2015 Sep-Oct
Mucuna pruriens in Parkinson Disease: A Kinetic-Dynamic Comparison With Levodopa Standard Formulations.
Clinical neuropharmacology
Open PubMedPMID 41220013 • 2025 Nov 1
Dopamine Dysregulation Syndrome in Parkinson's Disease.
The Senior care pharmacist
Open PubMedPMID 19207619 • 2010 Feb
Effect of Mucuna pruriens on oxidative stress mediated damage in aged rat sperm.
International journal of andrology
Open PubMedBenefit reports: 4
Adverse reports: 4
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Natural L-DOPA source — powerful but respect it like a medication. Excellent for short cycles or fertility support. Not for indefinite daily use. | Step2: Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
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Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=mucuna%20pruriens
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 10 mg-200 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Legacy community note: Popular for skin and joint health. Users report more hydrated skin and reduced joint stiffness. Often stacked with collagen for synergistic beauty benefits. Topical HA also widely used.
Sentiment Score
0.21000000000000002/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
aggregate • unclear
Aggregate community signal: 10 directional mentions (benefit 4, adverse 4, no-effect 1, mixed 1).
Open mentionamazon
Amazon search for Mucuna Pruriens (Velvet Bean)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
RCT • 2010 • Adults
75 infertile men under psychological stress.
Outcome: 5 g/day Mucuna seed powder for 3 months significantly reduced cortisol (−28%), improved sperm quality, and increased testosterone (+38%) and dopamine (+69%).[1897,1918,1993, etc.]
Open sourceRCT • 2009 • Adults
120 infertile vs 60 fertile men.
Outcome: Mucuna 5 g/day significantly improved sperm count (+56%), motility (+46%), and seminal antioxidant status in infertile men.[1897,1918,1993, etc.]
Open sourceMECHANISTIC • 2012 • Adults
Preclinical and clinical review.
Outcome: Mucuna-derived L-DOPA crosses BBB, upregulates dopamine synthesis, shows comparable efficacy to synthetic L-DOPA for Parkinson's symptoms in small clinical studies.[1897,1918,1993, etc.]
Open sourcePUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 12, RCTs 3, meta-analyses 0.[1897,1918,1993, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28679598 from Neurology.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41269916 from Journal of Parkinson's disease.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29352722 from Parkinsonism & related disorders.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35939305 from JAMA neurology.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38462520 from Internal medicine (Tokyo, Japan).
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41575577 from Amino acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32179240 from Parkinsonism & related disorders.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31796973 from Southern medical journal.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29427634 from Journal of ethnopharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26366963 from Clinical neuropharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41220013 from The Senior care pharmacist.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 19207619 from International journal of andrology.
Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]
Open source