Essential cofactor for MnSOD (mitochondrial antioxidant), arginase, pyruvate carboxylase, and glycosyltransferases critical for cartilage and bone matrix synthesis.[1345,1453,1454, etc.]
Bone HealthJoint HealthMetabolic Healthalias: Mnalias: manganese bisglycinatealias: manganese citrate
jointmetabolic
Composite Rating
3.7/5
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-22
Caution Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 6 • links 212
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Implementation Blueprint
Goal alignment: Bone Health, Joint Health, Metabolic Health.[564,712,936, etc.]
Interaction check: iron supplements (competitive absorption)[564,712,936, etc.]
ODS safety note: Manganese is taken up by the liver and other tissues, but the mechanism of this process is not well understood [ 1 , 2 ].[564,712,936, etc.]
ODS safety note: The liver, pancreas, kidney, and brain also contain manganese.[564,712,936, etc.]
ODS safety note: Groups at Risk of Manganese Inadequacy No known groups of people are likely to have inadequate manganese intakes.[564,712,936, etc.]
ODS safety note: Manganese and Health Because of the role of manganese as a cofactor for several enzymes, low intakes might increase the risk of illness.[564,712,936, etc.]
ODS safety note: Therefore, scientists have examined whether manganese status affects the risk of diabetes.[564,712,936, etc.]
ODS safety note: Health Risks from Excessive Manganese No evidence shows manganese toxicity from high dietary manganese intakes [ 38 ].[564,712,936, etc.]
ODS safety note: However, manganese toxicity has occurred in people working in such occupations as welding and mining who were exposed to high amounts of manganese from chronic inhalation of manganese dust [ 1 , 39 ].[564,712,936, etc.]
Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy.
Possible risk modifications in the association between MnSOD Ala-9Val polymorphism and breast cancer risk: subgroup analysis and evidence-based sample size calculation for a future trial.
Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant.
Essential trace mineral but supplementation rarely needed. Excess is dangerous. Usually adequate from diet (nuts, whole grains, tea). | Step2: Insufficient empirical signal for a directional adjustment.
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Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 10.0/10 (manual mapping confidence 1.00).
Legacy community note: One of the most popular and praised adaptogens. Users consistently report dramatic stress reduction, better sleep, improved gym performance, and enhanced libido. KSM-66 specifically recommended as the best extract.
1. Manganese, calcium, zinc, copper combination and bone mineral density
RCT • 1994 • Adults
59 postmenopausal women over 2 years.
Outcome: Trace mineral combination including Mn significantly prevented spinal bone loss vs calcium alone; Mn contribution via MnSOD and cartilage synthesis.[1345,1453,1454, etc.]
Open source 2. Manganese intake and diabetes risk: NHANES analysis
COHORT • 2021 • Adults
5202 adults from NHANES.
Outcome: Adequate manganese intake associated with 32% lower T2DM risk; MnSOD deficiency linked to impaired beta-cell function.[1345,1453,1454, etc.]
Open source 4. Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals.
PUBMED • 2026 • Human evidence curation set
PMID 41380425 from The journal of nutrition, health & aging.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 5. Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial.
PUBMED • 2021 • Human evidence curation set
PMID 33250314 from Phytomedicine : international journal of phytotherapy and phytopharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
PMID 35365361 from Clinical nutrition (Edinburgh, Scotland).
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 7. Antioxidant micronutrient supplements for adult critically ill patients: A bayesian multiple treatment comparisons meta-analysis.
PUBMED • 2022 • Human evidence curation set
PMID 35063246 from Clinical nutrition ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 8. The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.
PUBMED • 2023 • Human evidence curation set
PMID 36902266 from International journal of molecular sciences.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 9. Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy.
PUBMED • 2017 • Human evidence curation set
PMID 28949421 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 10. Human Milk Micronutrients and Child Growth and Body Composition in the First 2 years: A Systematic Review.
PUBMED • 2024 • Human evidence curation set
PMID 37315898 from Advances in nutrition (Bethesda, Md.).
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 11. Change in Mineral Status After Bariatric Surgery: a Meta-analysis.
PUBMED • 2023 • Human evidence curation set
PMID 37872256 from Obesity surgery.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 12. Clinical trials of vitamin-mineral supplementations in people with epilepsy: A systematic review.
PUBMED • 2021 • Human evidence curation set
PMID 33168326 from Clinical nutrition (Edinburgh, Scotland).
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 13. Australasian Society for Parenteral and Enteral Nutrition guidelines for supplementation of trace elements during parenteral nutrition.
PUBMED • 2014 • Human evidence curation set
PMID 25516311 from Asia Pacific journal of clinical nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 14. Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis.
PUBMED • 2014 • Human evidence curation set
PMID 24144963 from Alzheimer's & dementia : the journal of the Alzheimer's Association.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 15. Actual Data on Essential Trace Elements in Parkinson's Disease.
PUBMED • 2025 • Human evidence curation set
PMID 40507121 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 16. Possible risk modifications in the association between MnSOD Ala-9Val polymorphism and breast cancer risk: subgroup analysis and evidence-based sample size calculation for a future trial.
PUBMED • 2011 • Human evidence curation set
PMID 20567899 from Breast cancer research and treatment.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 17. The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review.
PUBMED • 2019 • Human evidence curation set
PMID 30909645 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 18. The Association between Diet and Hepatocellular Carcinoma: A Systematic Review.
PUBMED • 2021 • Human evidence curation set
PMID 33430001 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 19. Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review.
PUBMED • 2019 • Human evidence curation set
PMID 30959950 from Molecules (Basel, Switzerland).
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 20. Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial.
PUBMED • 2025 • Human evidence curation set
PMID 40555748 from Nature medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 21. Beneficial Role of Resveratrol on Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
PUBMED • 2025 • Human evidence curation set
PMID 40877487 from Reproductive sciences (Thousand Oaks, Calif.).
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 22. Nutrition, Obesity, and Seborrheic Dermatitis: Systematic Review.
PUBMED • 2024 • Human evidence curation set
PMID 39102684 from JMIR dermatology.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 23. Micronutrients and Androgenetic Alopecia: A Systematic Review.
PUBMED • 2024 • Human evidence curation set
PMID 39440586 from Molecular nutrition & food research.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 24. How important are elements in polycystic ovary syndrome? Should they be supplemented? A systematic review.
PUBMED • 2024 • Human evidence curation set
PMID 37713235 from Ginekologia polska.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 25. Nutritional supplements and mother's milk composition: a systematic review of interventional studies.
PUBMED • 2021 • Human evidence curation set
PMID 33397426 from International breastfeeding journal.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 26. Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.
PUBMED • 2020 • Human evidence curation set
PMID 32123972 from Urolithiasis.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 27. Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant.
PUBMED • 2025 • Human evidence curation set
PMID 40325900 from The Prostate.
Outcome: See linked PubMed abstract for methods and outcomes.[1345,1453,1454, etc.]
Open source 28. Myo-inositol, D-chiro-inositol, folic acid and manganese in second trimester of pregnancy: a preliminary investigation.
RCT • 2014 • PubMed indexed study
PMID 24488919 from European review for medical and pharmacological sciences.
Outcome: Study design: RCT. Quality score: 8.6/10.[1345,1453,1454, etc.]
Open source 29. [NUTRITIONAL COMPONENTS AND MACULAR DEGENERATION AGE-RELATED].
SYSTEMATIC_REVIEW • 2015 • PubMed indexed study
PMID 26262695 from Nutricion hospitalaria.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1345,1453,1454, etc.]
Open source 30. Recommendations for Manganese Supplementation to Adult Patients Receiving Long-Term Home Parenteral Nutrition: An Analysis of the Supporting Evidence.
SYSTEMATIC_REVIEW • 2016 • PubMed indexed study
PMID 26203074 from Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1345,1453,1454, etc.]
Open source 31. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.
RCT • 1992 • PubMed indexed study
PMID 1307234 from The New England journal of medicine.
Outcome: Study design: RCT. Quality score: 8.5/10.[1345,1453,1454, etc.]
Open source 32. Influence of a drink containing different antioxidants and Lactobacillus plantarum 299v on plasma total antioxidant capacity, selenium status and faecal microbial flora.
RCT • 2003 • PubMed indexed study
PMID 12850889 from International journal of food sciences and nutrition.
Outcome: Study design: RCT. Quality score: 8.5/10.[1345,1453,1454, etc.]
Open source 33. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials.
SYSTEMATIC_REVIEW • 2006 • PubMed indexed study
PMID 16670364 from The Annals of pharmacotherapy.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.5/10.[1345,1453,1454, etc.]
Open source 34. Berry supplementation in healthy volunteers modulates gut microbiota, increases fecal polyphenol metabolites and reduces viability of colon cancer cells exposed to fecal water- a randomized controlled trial.
RCT • 2025 • PubMed indexed study
PMID 40120775 from The Journal of nutritional biochemistry.
Outcome: Study design: RCT. Quality score: 8.4/10.[1345,1453,1454, etc.]
Open source 35. Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized controlled trial.
RCT • 2004 • PubMed indexed study
PMID 15448423 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 36. Manganese absorption in humans: the effect of phytic acid and ascorbic acid in soy formula.
RCT • 1995 • PubMed indexed study
PMID 7572746 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 37. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals.
RCT • 1994 • PubMed indexed study
PMID 8027856 from The Journal of nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 38. Multiple micronutrient supplementation increases the growth of Mexican infants.
RCT • 2001 • PubMed indexed study
PMID 11684535 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 39. High- versus low-meat diets: effects on zinc absorption, iron status, and calcium, copper, iron, magnesium, manganese, nitrogen, phosphorus, and zinc balance in postmenopausal women.
RCT • 1995 • PubMed indexed study
PMID 7661125 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 40. An estimation of mineral losses through arm sweat of preadolescent children.
RCT • 1976 • PubMed indexed study
PMID 941865 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1345,1453,1454, etc.]
Open source 41. Vitamin D Treatment during Pregnancy and Maternal and Neonatal Cord Blood Metal Concentrations at Delivery: Results of a Randomized Controlled Trial in Bangladesh.
RCT • 2020 • PubMed indexed study
PMID 33226277 from Environmental health perspectives.
Outcome: Study design: RCT. Quality score: 8.0/10.[1345,1453,1454, etc.]
Open source 42. Plasma Concentration of Essential and Toxic Trace Elements After Brazil Nut Intake: Results from a Randomized Controlled Trial.
RCT • 2023 • PubMed indexed study
PMID 35488024 from Biological trace element research.
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 43. Manganese restriction in parenteral nutrition for preterm neonates: A pilot randomized controlled trial.
RCT • 2025 • PubMed indexed study
PMID 39967248 from Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 44. Fostering healthy aging through selective nutrition: A long-term comparison of two dietary patterns and their holistic impact on mineral status in middle-aged individuals-A randomized controlled intervention trial in Germany.
RCT • 2024 • PubMed indexed study
PMID 38701651 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 45. Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population.
RCT • 2010 • PubMed indexed study
PMID 20233853 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 46. Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial.
RCT • 2010 • PubMed indexed study
PMID 20200432 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 47. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study.
RCT • 2007 • PubMed indexed study
PMID 17646272 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: RCT. Quality score: 7.8/10.[1345,1453,1454, etc.]
Open source 48. Vitamins and minerals intake adequacy in hematopoietic stem cell transplant: results of a randomized controlled trial.
RCT • 2021 • PubMed indexed study
PMID 33257778 from Bone marrow transplantation.
Outcome: Study design: RCT. Quality score: 7.7/10.[1345,1453,1454, etc.]
Open source 49. Daily consumption of pistachios over 12 weeks improves dietary profile without increasing body weight in healthy women: A randomized controlled intervention.
RCT • 2020 • PubMed indexed study
PMID 31604062 from Appetite.
Outcome: Study design: RCT. Quality score: 7.7/10.[1345,1453,1454, etc.]
Open source 50. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain.
RCT • 2022 • PubMed indexed study
PMID 33568038 from Endocrine, metabolic & immune disorders drug targets.
Outcome: Study design: RCT. Quality score: 7.7/10.[1345,1453,1454, etc.]
Open source 51. The effects of antioxidant vitamin supplementation on expiratory flow rates at rest and during exercise.
RCT • 2015 • PubMed indexed study
PMID 25987441 from European journal of applied physiology.
Outcome: Study design: RCT. Quality score: 7.6/10.[1345,1453,1454, etc.]
Open source 52. EFFECTS AND MECHANISMS OF A NEW MULTIVITAMIN ON CHRONIC METABOLIC SYNDROMES AND AGING.
RCT • 2017 • PubMed indexed study
PMID 28331914 from African journal of traditional, complementary, and alternative medicines : AJTCAM.
Outcome: Study design: RCT. Quality score: 7.6/10.[1345,1453,1454, etc.]
Open source 53. Long alimentary limb duodenal switch (LADS): a short-term prospective randomized trial.
RCT • 2018 • PubMed indexed study
PMID 29217129 from Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.
Outcome: Study design: RCT. Quality score: 7.6/10.[1345,1453,1454, etc.]
Open source 54. Manganese intake and cholestatic jaundice in neonates receiving parenteral nutrition: a randomized controlled study.
RCT • 2001 • PubMed indexed study
PMID 11683188 from Acta paediatrica (Oslo, Norway : 1992).
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 55. Changes in blood manganese levels during pregnancy in iron supplemented and non supplemented women.
RCT • 1995 • PubMed indexed study
PMID 8846152 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 56. Serum trace element levels in COPD patient: the relation between trace element supplementation and period of mechanical ventilation in a randomized controlled trial.
RCT • 2009 • PubMed indexed study
PMID 19761535 from Respirology (Carlton, Vic.).
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 57. The influence of vitamins and trace element supplements on the stability of the pre-corneal tear film.
RCT • 1993 • PubMed indexed study
PMID 8154260 from Acta ophthalmologica.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 58. Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women.
RCT • 2009 • PubMed indexed study
PMID 19126424 from Toxicology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 59. Exercise and mononuclear cell DNA damage: the effects of antioxidant supplementation.
RCT • 2005 • PubMed indexed study
PMID 16327031 from International journal of sport nutrition and exercise metabolism.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 60. Oral manganese for liver imaging at three different field strengths.
RCT • 2004 • PubMed indexed study
PMID 15172365 from Academic radiology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 61. [Prevention of the first occurrence of anencephaly and spina bifida with periconceptional multivitamin supplementation (conclusion)].
RCT • 1994 • PubMed indexed study
PMID 7970646 from Orvosi hetilap.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 62. Effect of lactose on mineral absorption in preterm infants.
RCT • 1990 • PubMed indexed study
PMID 2199643 from The Journal of pediatrics.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 63. Blood plasma concentrations of microelements in endurance trained volunteers during hypokinesia and chronic hyperhydration.
RCT • 1994 • PubMed indexed study
PMID 7946917 from Biological trace element research.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 64. [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial].
RCT • 2004 • PubMed indexed study
PMID 15658548 from Terapevticheskii arkhiv.
Outcome: Study design: RCT. Quality score: 7.5/10.[1345,1453,1454, etc.]
Open source 65. Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults.
RCT • 2020 • PubMed indexed study
PMID 32939005 from Scientific reports.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.3/10.[1345,1453,1454, etc.]
Open source 66. Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas.
RCT • 1989 • PubMed indexed study
PMID 2758010 from The British journal of nutrition.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.1/10.[1345,1453,1454, etc.]
Open source 67. Plasma Manganese Levels and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study.
COHORT • 2022 • PubMed indexed study
PMID 36215214 from Environmental science & technology.
Outcome: Study design: COHORT. Quality score: 6.7/10.[1345,1453,1454, etc.]
Open source 68. The Inflammatory Potential of Dietary Manganese in a Cohort of Elderly Men.
RCT • 2018 • PubMed indexed study
PMID 28822065 from Biological trace element research.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.6/10.[1345,1453,1454, etc.]
Open source 69. Dietary calcium and manganese effects on menstrual cycle symptoms.
RCT • 1993 • PubMed indexed study
PMID 8498421 from American journal of obstetrics and gynecology.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.5/10.[1345,1453,1454, etc.]
Open source 70. Oral manganese intake estimated with dietary records and with direct chemical analysis.
COHORT • 2002 • PubMed indexed study
PMID 11883756 from The Science of the total environment.
Outcome: Study design: COHORT. Quality score: 6.5/10.[1345,1453,1454, etc.]
Open source 71. Relationship between dietary magnesium, manganese, and copper and metabolic syndrome risk in Korean adults: the Korea National Health and Nutrition Examination Survey (2007-2008).
RCT • 2013 • PubMed indexed study
PMID 24218228 from Biological trace element research.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.5/10.[1345,1453,1454, etc.]
Open source 72. Impact of nutrition counselling and supplements on the mineral nutriture of rural pregnant women and their neonates.
RCT • 1994 • PubMed indexed study
PMID 7896386 from Indian pediatrics.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.5/10.[1345,1453,1454, etc.]
Open source 73. Dietary manganese intake is positively associated with metabolic dysfunction-associated steatotic liver disease: a multicohort study.
COHORT • 2025 • PubMed indexed study
PMID 40419737 from European journal of nutrition.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1345,1453,1454, etc.]
Open source 74. Association of dietary manganese intake and the IL1R1 rs3917225 polymorphism with thyroid cancer risk: a prospective cohort study in Korea.
COHORT • 2024 • PubMed indexed study
PMID 39534923 from The British journal of nutrition.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1345,1453,1454, etc.]
Open source 75. Concentrations and predictors of select nutrients in Canadian human milk samples from the Maternal-Infant Research on Environmental Chemicals pregnancy cohort.
COHORT • 2024 • PubMed indexed study
PMID 39362363 from The American journal of clinical nutrition.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1345,1453,1454, etc.]
Open source 76. A multisite community-based, case-control study to examine the nutrient intake adequacy of young children with and without developmental delays and other disorders: findings from the Study to Explore Early Development (SEED).
COHORT • 2025 • PubMed indexed study
PMID 39978468 from The American journal of clinical nutrition.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1345,1453,1454, etc.]
Open source 77. Association between blood heavy metal element and all-cause mortality in asthmatic adults: a cohort study.
COHORT • 2024 • PubMed indexed study
PMID 39227630 from Scientific reports.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1345,1453,1454, etc.]
Open source 78. Dietary Manganese, Plasma Markers of Inflammation, and the Development of Type 2 Diabetes in Postmenopausal Women: Findings From the Women's Health Initiative.
COHORT • 2020 • PubMed indexed study
PMID 32295807 from Diabetes care.
Outcome: Study design: COHORT. Quality score: 6.3/10.[1345,1453,1454, etc.]
Open source 79. The Role of Manganese in Very Low Birth Weight Infants.
COHORT • 2022 • PubMed indexed study
PMID 35930026 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: COHORT. Quality score: 6.3/10.[1345,1453,1454, etc.]
Open source 80. A comparison of dietary intake between personnel of a gas processing company and a sample population of public employees from Mashhad.
COHORT • 2020 • PubMed indexed study
PMID 32690146 from Clinical nutrition ESPEN.
Outcome: Study design: COHORT. Quality score: 6.3/10.[1345,1453,1454, etc.]
Open source 81. Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study.
COHORT • 2020 • PubMed indexed study
PMID 33101589 from Oxidative medicine and cellular longevity.
Outcome: Study design: CASE_CONTROL. Quality score: 6.2/10.[1345,1453,1454, etc.]
Open source 82. The Association between Dietary Vitamin C/E and Gestational Hypertensive Disorder: A Case-Control Study.
COHORT • 2018 • PubMed indexed study
PMID 30606968 from Journal of nutritional science and vitaminology.
Outcome: Study design: CASE_CONTROL. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 83. Food Group Consumption and Nutrient Intake by Breastfeeding Women: Comparison to Current Dietary Guidelines and Nutrient Recommendations.
COHORT • 2025 • PubMed indexed study
PMID 39940233 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 84. Nutrients, Diet Quality, and Dietary Patterns in Patients with Inflammatory Bowel Disease: A Comparative Analysis.
COHORT • 2024 • PubMed indexed study
PMID 39339692 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 85. Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.
COHORT • 2024 • PubMed indexed study
PMID 38780454 from Environmental health perspectives.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 86. Diet-Wide Association, Genetic Susceptibility and Colorectal Cancer Risk: A Prospective Cohort Study.
COHORT • 2023 • PubMed indexed study
PMID 38004195 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 87. Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.
COHORT • 2023 • PubMed indexed study
PMID 37686882 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1345,1453,1454, etc.]
Open source 88. The association between dietary mineral intake and the risk of preeclampsia in Chinese pregnant women: a matched case-control study.
COHORT • 2023 • PubMed indexed study
PMID 37752229 from Scientific reports.
Outcome: Study design: CASE_CONTROL. Quality score: 5.9/10.[1345,1453,1454, etc.]
Open source 89. Relationships between minerals' intake and blood homocysteine levels based on three machine learning methods: a large cross-sectional study.
COHORT • 2024 • PubMed indexed study
PMID 38824142 from Nutrition & diabetes.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.9/10.[1345,1453,1454, etc.]
Open source 90. Association between serum iron, blood lead, cadmium, mercury, selenium, manganese and low cognitive performance in old adults from National Health and Nutrition Examination Survey (NHANES): a cross-sectional study.
COHORT • 2023 • PubMed indexed study
PMID 36941743 from The British journal of nutrition.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.9/10.[1345,1453,1454, etc.]
Open source 91. Positive association between dietary manganese intake and new-onset hypertension: A nationwide cohort study in China.
COHORT • 2024 • PubMed indexed study
PMID 38161121 from Nutrition, metabolism, and cardiovascular diseases : NMCD.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 92. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
COHORT • 2022 • PubMed indexed study
PMID 36269752 from PloS one.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 93. Associations of dietary mineral intakes with the risk of six common mental disorders: A prospective cohort study.
COHORT • 2026 • PubMed indexed study
PMID 40925482 from Journal of affective disorders.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 94. Long-term relatively high dietary manganese intake could decrease the risk of hyperuricemia: Twelve-year distinct dietary manganese consumption trajectories and the China Health and Nutrition Survey.
COHORT • 2024 • PubMed indexed study
PMID 38866616 from Nutrition, metabolism, and cardiovascular diseases : NMCD.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 95. The Role of Selected Elements in Oxidative Stress Protection: Key to Healthy Fertility and Reproduction.
PUBMED • 2024 • PubMed indexed study
PMID 39273356 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 96. Menstrual Cycle-Associated Changes in Micronutrient Biomarkers Concentration: A Prospective Cohort Study.
COHORT • 2023 • PubMed indexed study
PMID 35512771 from Journal of the American Nutrition Association.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1345,1453,1454, etc.]
Open source 97. Association between Dietary Manganese Intake and Mortality from Cardiovascular Disease in Japanese Population: The Japan Collaborative Cohort Study.
COHORT • 2022 • PubMed indexed study
PMID 35082202 from Journal of atherosclerosis and thrombosis.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1345,1453,1454, etc.]
Open source 98. Using Guduchi (Tinospora cordifolia) as an eco-friendly feed supplement in human and poultry nutrition.
PUBMED • 2020 • PubMed indexed study
PMID 32029162 from Poultry science.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1345,1453,1454, etc.]
Open source 99. Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass.
PUBMED • 2022 • PubMed indexed study
PMID 35563167 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1345,1453,1454, etc.]
Open source 100. Evaluation of micronutrient levels in children with cerebral palsy.
COHORT • 2022 • PubMed indexed study
PMID 34585809 from Pediatrics international : official journal of the Japan Pediatric Society.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1345,1453,1454, etc.]
Open source 101. Dietary Intake Levels of Iron, Copper, Zinc, and Manganese in Relation to Cognitive Function: A Cross-Sectional Study.
COHORT • 2023 • PubMed indexed study
PMID 36771411 from Nutrients.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.6/10.[1345,1453,1454, etc.]
Open source 102. A Cross-Sectional Study on Protein Substitutes for Paediatric Phenylketonuria Diet: Time to Pay Attention.
COHORT • 2025 • PubMed indexed study
PMID 40507036 from Nutrients.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.6/10.[1345,1453,1454, etc.]
Open source 103. Association between Mineral Intake and Cognition Evaluated by Montreal Cognitive Assessment (MoCA): A Cross-Sectional Study.
COHORT • 2023 • PubMed indexed study
PMID 37960158 from Nutrients.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.6/10.[1345,1453,1454, etc.]
Open source 104. The Impact of Dietary Transition Metals on Host-Bacterial Interactions.
PUBMED • 2018 • PubMed indexed study
PMID 29902439 from Cell host & microbe.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.6/10.[1345,1453,1454, etc.]
Open source 105. Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China.
COHORT • 2018 • PubMed indexed study
PMID 29971528 from Diabetologia.
Outcome: Study design: COHORT. Quality score: 5.6/10.[1345,1453,1454, etc.]
Open source 106. A biokinetic model for manganese.
PUBMED • 2011 • PubMed indexed study
PMID 21802707 from The Science of the total environment.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 108. Wheat germ: not only a by-product.
PUBMED • 2012 • PubMed indexed study
PMID 22077851 from International journal of food sciences and nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 109. The importance of antioxidant micronutrients in pregnancy.
PUBMED • 2011 • PubMed indexed study
PMID 21918714 from Oxidative medicine and cellular longevity.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 110. Metal ions and infectious diseases. An overview from the clinic.
PUBMED • 2013 • PubMed indexed study
PMID 24470087 from Metal ions in life sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 111. Dietary Antioxidant Intake and Human Papillomavirus Infection: Evidence from a Cross-Sectional Study in Italy.
COHORT • 2020 • PubMed indexed study
PMID 32408636 from Nutrients.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 112. Old age, malnutrition, and pressure sores: an ill-fated alliance.
PUBMED • 2004 • PubMed indexed study
PMID 15071079 from The journals of gerontology. Series A, Biological sciences and medical sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 113. Clinical implications of trace elements in endocrinology.
COHORT • 1992 • PubMed indexed study
PMID 1375054 from Biological trace element research.
Outcome: Study design: COHORT. Quality score: 5.5/10.[1345,1453,1454, etc.]
Open source 114. Manganese in the Diet: Bioaccessibility, Adequate Intake, and Neurotoxicological Effects.
PUBMED • 2020 • PubMed indexed study
PMID 32298096 from Journal of agricultural and food chemistry.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 115. Association of dietary intake and whole blood essential trace elements with frailty in older adults: a cross-sectional study.
COHORT • 2025 • PubMed indexed study
PMID 40632367 from Aging clinical and experimental research.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 116. Manganese-engineered Lactobacillus Reuteri with enhanced antitumor and immunomodulatory activities for colorectal cancer prevention and treatment.
PUBMED • 2025 • PubMed indexed study
PMID 41413024 from Nature communications.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 117. SLC10A7 regulates O-GalNAc glycosylation and Ca(2+) homeostasis in the secretory pathway: insights into SLC10A7-CDG.
PUBMED • 2025 • PubMed indexed study
PMID 39779512 from Cellular and molecular life sciences : CMLS.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 118. Spirulina and Chlorella Dietary Supplements-Are They a Source Solely of Valuable Nutrients?
PUBMED • 2025 • PubMed indexed study
PMID 41226507 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 119. The relationship between dietary habits and menstruation problems in women: a cross-sectional study.
COHORT • 2024 • PubMed indexed study
PMID 38997663 from BMC women's health.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 120. Astrocytes in heavy metal neurotoxicity and neurodegeneration.
PUBMED • 2021 • PubMed indexed study
PMID 33412145 from Brain research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 121. Plasma levels and dietary intake of minerals in patients with type 2 diabetes and chronic kidney disease: A case-control study.
COHORT • 2024 • PubMed indexed study
PMID 38484635 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: CASE_CONTROL. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 122. Correlation of Dietary Macro- and Micro-Mineral Intake with Seminal Plasma Quality/Quantity and Oxidant/Antioxidant Status in Infertile Compared to the Normal Men: a Case-Control Study.
COHORT • 2024 • PubMed indexed study
PMID 37721681 from Biological trace element research.
Outcome: Study design: CASE_CONTROL. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 123. Association between blood manganese levels and depressive symptoms among US adults: A nationally representative cross-sectional study.
COHORT • 2023 • PubMed indexed study
PMID 37084963 from Journal of affective disorders.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 124. The Interplay of Sulfur and Selenium Enabling Variations in Micronutrient Accumulation in Red Spinach.
PUBMED • 2023 • PubMed indexed study
PMID 37628947 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1345,1453,1454, etc.]
Open source 125. Bright ferritin for long-term MR imaging of human embryonic stem cells.
PUBMED • 2023 • PubMed indexed study
PMID 37964388 from Stem cell research & therapy.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1345,1453,1454, etc.]
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 127. Dietary manganese intake is inversely associated with depressive symptoms in midlife women: A cross-sectional study.
COHORT • 2020 • PubMed indexed study
PMID 32739710 from Journal of affective disorders.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 128. Maternal metal intake during pregnancy and childhood behavioral problems in Japan: the Kyushu Okinawa Maternal and Child Health Study.
PUBMED • 2022 • PubMed indexed study
PMID 33568010 from Nutritional neuroscience.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 129. Rice: Importance for Global Nutrition.
PUBMED • 2019 • PubMed indexed study
PMID 31619630 from Journal of nutritional science and vitaminology.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 130. [Nutritional Assessment and Management for Patients with Chronic Liver Disease].
PUBMED • 2018 • PubMed indexed study
PMID 29684966 from The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 131. Dietary and drinking water intake of essential trace elements in a typical Kashin-Beck disease endemic area of Tibet, China.
PUBMED • 2022 • PubMed indexed study
PMID 36114578 from Environmental health : a global access science source.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 132. Manganese-Labeled Alginate Hydrogels for Image-Guided Cell Transplantation.
PUBMED • 2022 • PubMed indexed study
PMID 35269609 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 133. Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project.
PUBMED • 2019 • PubMed indexed study
PMID 31455712 from BMJ open.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Open source 134. Spermine protects alpha-synuclein expressing dopaminergic neurons from manganese-induced degeneration.
PUBMED • 2019 • PubMed indexed study
PMID 30673990 from Cell biology and toxicology.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1345,1453,1454, etc.]
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 136. The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium.
PUBMED • 2024 • PubMed indexed study
PMID 39683514 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 137. Dietary standards for manganese: overlap between nutritional and toxicological studies.
PUBMED • 1998 • PubMed indexed study
PMID 9478027 from The Journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 138. Copper, iron, zinc, and manganese in dietary supplements, infant formulas, and ready-to-eat breakfast cereals.
PUBMED • 1998 • PubMed indexed study
PMID 9587148 from The American journal of clinical nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 139. The Impact of Nutritional Components on Periodontal Health: A Literature Review.
PUBMED • 2024 • PubMed indexed study
PMID 39599688 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 140. Trace element deficiency and toxicity.
PUBMED • 1998 • PubMed indexed study
PMID 10565401 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 141. Is manganese an essential supplement for parenteral nutrition?
PUBMED • 2008 • PubMed indexed study
PMID 18403926 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 142. Maternal and umbilical cord blood levels of mercury, manganese, iron, and copper in southern Taiwan: A cross-sectional study.
COHORT • 2017 • PubMed indexed study
PMID 27889462 from Journal of the Chinese Medical Association : JCMA.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 143. Parenteral trace elements in children: clinical aspects and dosage recommendations.
PUBMED • 2012 • PubMed indexed study
PMID 22895278 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 144. What is known about the safety of multivitamin-multimineral supplements for the generally healthy population? Theoretical basis for harm.
PUBMED • 2007 • PubMed indexed study
PMID 17209218 from The American journal of clinical nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 145. Role of trace elements in hepatic encephalopathy: zinc and manganese.
PUBMED • 2003 • PubMed indexed study
PMID 15025250 from Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 146. Dietary Trace Elements and the Pathogenesis of Neurodegenerative Diseases.
PUBMED • 2023 • PubMed indexed study
PMID 37432185 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 147. Chemometric analysis of minerals in gluten-free products.
PUBMED • 2018 • PubMed indexed study
PMID 29194641 from Journal of the science of food and agriculture.
Outcome: Study design: OTHER. Quality score: 5.1/10.[1345,1453,1454, etc.]
Open source 148. Mineral Micronutrients in Asthma.
PUBMED • 2021 • PubMed indexed study
PMID 34836256 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 149. Essential trace elements and progression and management of HIV infection.
PUBMED • 2019 • PubMed indexed study
PMID 31668643 from Nutrition research (New York, N.Y.).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 150. Advances in Trace Element Supplementation for Parenteral Nutrition.
PUBMED • 2022 • PubMed indexed study
PMID 35565737 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 151. Daily dietary intake of iron, copper, zinc and manganese in a Spanish population.
PUBMED • 2009 • PubMed indexed study
PMID 19817638 from International journal of food sciences and nutrition.
Outcome: Study design: OTHER. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 152. Effects of Total Enteral Nutrition on Early Growth, Immunity, and Neuronal Development of Preterm Infants.
PUBMED • 2021 • PubMed indexed study
PMID 34444915 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 153. Environmental Metal Exposure, Neurodevelopment, and the Role of Iron Status: a Review.
PUBMED • 2022 • PubMed indexed study
PMID 35997893 from Current environmental health reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 154. Toenails as biomarker of exposure to essential trace metals: A review.
PUBMED • 2019 • PubMed indexed study
PMID 31610392 from Environmental research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 155. Dietary Micronutrients from Zygote to Senility: Updated Review of Minerals' Role and Orchestration in Human Nutrition throughout Life Cycle with Sex Differences.
PUBMED • 2021 • PubMed indexed study
PMID 34835995 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 156. Sustainable management of cadmium-contaminated soils as affected by exogenous application of nutrients: A review.
PUBMED • 2021 • PubMed indexed study
PMID 34171783 from Journal of environmental management.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1345,1453,1454, etc.]
Open source 157. Association of dietary manganese intake with new-onset chronic kidney disease in participants with diabetes.
PUBMED • 2024 • PubMed indexed study
PMID 39413577 from Diabetes & metabolic syndrome.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 158. Zinc, Copper, and Manganese Homeostasis and Potential Trace Metal Accumulation in Dairy Cows: Longitudinal Study from Late Lactation to Subsequent Mid-Lactation.
PUBMED • 2023 • PubMed indexed study
PMID 36813237 from The Journal of nutrition.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 159. Trace Elements in Parenteral Nutrition: Considerations for the Prescribing Clinician.
PUBMED • 2017 • PubMed indexed study
PMID 28452962 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 160. Trace Element Provision in Parenteral Nutrition in Children: One Size Does Not Fit All.
PUBMED • 2018 • PubMed indexed study
PMID 30469420 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 161. Micronutrient status in type 2 diabetes: a review.
PUBMED • 2014 • PubMed indexed study
PMID 24484939 from Advances in food and nutrition research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 162. The tolerable upper intake level of manganese alleviates Parkinson-like motor performance and neuronal loss by activating mitophagy.
PUBMED • 2024 • PubMed indexed study
PMID 39401732 from Free radical biology & medicine.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 163. Manganese nanoparticles control the gene regulations against multiple stresses in Pangasianodon hypophthalmus.
PUBMED • 2023 • PubMed indexed study
PMID 37741912 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 164. Pulse and legume consumption is associated with a more optimal nutrient intake and a higher EAT-Lancet index in a representative UK population.
PUBMED • 2025 • PubMed indexed study
PMID 40133707 from European journal of nutrition.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 165. Manganese and Sleep Outcomes in United States Adults: Results from the 2017-2020 National Health and Nutrition Examination Survey (NHANES).
PUBMED • 2024 • PubMed indexed study
PMID 37984743 from The Journal of nutrition.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 166. Carcinogenic and non-carcinogenic health risk assessment of organic compounds and heavy metals in electronic cigarettes.
PUBMED • 2023 • PubMed indexed study
PMID 37749131 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 167. Aluminum and other chemical elements in parenteral nutrition components and all-in-one admixtures.
PUBMED • 2023 • PubMed indexed study
PMID 38411019 from Clinical nutrition (Edinburgh, Scotland).
Outcome: Study design: OTHER. Quality score: 4.9/10.[1345,1453,1454, etc.]
Open source 168. The role of nutrition in wound healing and implications for nursing practice.
PUBMED • 2025 • PubMed indexed study
PMID 39969834 from British journal of nursing (Mark Allen Publishing).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 169. International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance.
PUBMED • 2026 • PubMed indexed study
PMID 41701327 from Journal of the International Society of Sports Nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 170. A review on manganese and its effect on health and distribution in selected African countries.
PUBMED • 2025 • PubMed indexed study
PMID 40743625 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 171. A Review on Chemo Sensors and Fluorosensors for Manganese.
PUBMED • 2025 • PubMed indexed study
PMID 40332463 from Journal of fluorescence.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 172. Associations of Dietary Antioxidants with Glycated Hemoglobin and Insulin Sensitivity in Adults with and without Type 1 Diabetes.
PUBMED • 2022 • PubMed indexed study
PMID 35789593 from Journal of diabetes research.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 173. Assessment and management of magnesium and trace element status in children with CKD stages 2-5, on dialysis and post-transplantation: Clinical practice points from the Pediatric Renal Nutrition Taskforce.
PUBMED • 2025 • PubMed indexed study
PMID 40379985 from Pediatric nephrology (Berlin, Germany).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 174. Human papillomavirus infection, cervical cancer and the less explored role of trace elements.
PUBMED • 2023 • PubMed indexed study
PMID 35467267 from Biological trace element research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 175. Total intake of different minerals and the risk of multiple sclerosis.
PUBMED • 2019 • PubMed indexed study
PMID 30944237 from Neurology.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 176. Drug-induced osteoporosis and mechanisms of bone tissue regeneration through trace elements.
PUBMED • 2024 • PubMed indexed study
PMID 38615498 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 177. Daily and within-feed variation of macro- and trace-element concentrations in human milk and implications for sampling.
PUBMED • 2021 • PubMed indexed study
PMID 34166949 from Food chemistry.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 178. [Essential trace elements, vitamins, and selected electrolytes in complementary medicine for cancer patients].
PUBMED • 2023 • PubMed indexed study
PMID 36454272 from Urologie (Heidelberg, Germany).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 179. The micronutrient content in underutilized crops: the Lupinus mutabilis sweet case.
PUBMED • 2022 • PubMed indexed study
PMID 36071148 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 180. Dietary protein is the strong predictor of coronary artery disease; a data mining approach.
PUBMED • 2021 • PubMed indexed study
PMID 34024553 from Clinical nutrition ESPEN.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 181. The role of trace elements for the function and health of the skin.
PUBMED • 2025 • PubMed indexed study
PMID 40460725 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 182. A Comprehensive Review of the Importance of Selected Trace Elements Present in Edible Insects.
PUBMED • 2023 • PubMed indexed study
PMID 36109446 from Biological trace element research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 183. Deciphering the role of metal and non-metals in the treatment of epilepsy.
PUBMED • 2023 • PubMed indexed study
PMID 37178926 from Neurochemistry international.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 184. Therapeutic effect of trace elements on multiple myeloma and mechanisms of cancer process.
PUBMED • 2023 • PubMed indexed study
PMID 37567355 from Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1345,1453,1454, etc.]
Open source 185. Interactions between iron and manganese in neurotoxicity.
PUBMED • 2020 • PubMed indexed study
PMID 32180038 from Archives of toxicology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 186. Nutrition interventions in congenital disorders of glycosylation.
PUBMED • 2022 • PubMed indexed study
PMID 35562242 from Trends in molecular medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 187. Dietary Manganese Exposure in the Adult Population in Germany-What Does it Mean in Relation to Health Risks?
PUBMED • 2019 • PubMed indexed study
PMID 31216097 from Molecular nutrition & food research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 188. Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population.
PUBMED • 2016 • PubMed indexed study
PMID 27385039 from The British journal of nutrition.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 189. Dietary antioxidant for disease prevention corroborated by the Nrf2 pathway.
PUBMED • 2019 • PubMed indexed study
PMID 30726190 from Journal of complementary & integrative medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 190. Regulatory effects of transition metals supplementation/deficiency on the gut microbiota.
PUBMED • 2021 • PubMed indexed study
PMID 33449129 from Applied microbiology and biotechnology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 191. How much manganese is safe for infants? A review of the scientific basis of intake guidelines and regulations relevant to the manganese content of infant formulas.
PUBMED • 2021 • PubMed indexed study
PMID 33450552 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 192. Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients.
PUBMED • 2022 • PubMed indexed study
PMID 35901669 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 193. Dietary intake of patients with angiographically defined coronary artery disease and that of healthy controls in Iran.
PUBMED • 2014 • PubMed indexed study
PMID 24219895 from European journal of clinical nutrition.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 194. Bioelements in the treatment of burn injuries - The complex review of metabolism and supplementation (copper, selenium, zinc, iron, manganese, chromium and magnesium).
PUBMED • 2020 • PubMed indexed study
PMID 32739827 from Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 195. Analytical ingredient content and variability of adult multivitamin/mineral products: national estimates for the Dietary Supplement Ingredient Database.
PUBMED • 2017 • PubMed indexed study
PMID 27974309 from The American journal of clinical nutrition.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 196. [Nutrition in the prevention and control of osteoporosis].
PUBMED • 2021 • PubMed indexed study
PMID 32993301 from Nutricion hospitalaria.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 197. Nutrients and amyloid β status in the brain: A narrative review.
PUBMED • 2022 • PubMed indexed study
PMID 36049590 from Ageing research reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]
Open source 198. Role of Divalent Cations in HIV-1 Replication and Pathogenicity.
PUBMED • 2020 • PubMed indexed study
PMID 32326317 from Viruses.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1345,1453,1454, etc.]