Supplement
Supports electrolyte balance, enzymatic activity, and metabolic signaling.[2924,3114,4095, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
38/100
Early depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
51/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 4 • mentions 4 • links 14
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[531,679,903, etc.]
Dose guide: Human-study daily dose: 3 mg-500 mg/day (higher-confidence extraction from PubMed abstracts)..[531,679,903, etc.]
Category
Mineral
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 3 mg-500 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 5 • RCTs: 2 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 7 • Interactions: 1
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
9 total studies
Timeline
Total indexed
9
Safety adverse signals
7
Human studies
5
Randomized trials
2
In vitro / tissue
1
Interaction signals
1
Weighted direction score: 10 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Total indexed
9
Safety adverse signals
7
Human studies
5
Randomized trials
2
In vitro / tissue
1
Interaction signals
1
Animal-only studies
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 30280670 • 2018
Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial.
Curr Pediatr Rev
Open PubMedPMID 34171389 • 2021 Dec
Addition of oral iron bisglycinate to intravenous iron sucrose for the treatment of postpartum anemia-randomized controlled trial.
Am J Obstet Gynecol
Open PubMedPMID 29366419 • 2018
Efficacy of Supplementation with Iron Sulfate Compared to Iron Bisglycinate Chelate in Preterm Infants.
Curr Pediatr Rev
Open PubMedPMID 37299583 • 2023 Jun 3
Assessment of the Efficacy of a Low-Dose Iron Supplement in Restoring Iron Levels to Normal Range among Healthy Premenopausal Women with Iron Deficiency without Anemia.
Nutrients
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22iron%20bisglycinate%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22iron%20bisglycinate%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=iron%20bisglycinate
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 3 mg-500 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$10.00.
Legacy community note: Those with deficiency report life-changing energy improvements. Bisglycinate form specifically praised for being gentle. Strong warnings in community against supplementing without testing.
Sentiment Score
-0.3/100
Benefit Mentions
No benefit mentions recorded.
Adverse Mentions
No adverse mentions recorded.
Best Responders
No responder profile recorded.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Iron Bisglycinate
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 5, RCTs 2, meta-analyses 0.[2924,3114,4095, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30280670 from Curr Pediatr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2924,3114,4095, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34171389 from Am J Obstet Gynecol.
Outcome: See linked PubMed abstract for methods and outcomes.[2924,3114,4095, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29366419 from Curr Pediatr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2924,3114,4095, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37299583 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2924,3114,4095, etc.]
Open source