Supplement

Iodine

Supports electrolyte balance, enzymatic activity, and metabolic signaling.[2901,3127,3264, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Metabolic HealthEnergyHeart HealthLongevity

metabolicmitocardio

Composite Rating

3.7/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

-20

Caution Lean • confidence Minimal

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 15 • mentions 3 • links 25

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[530,678,902, etc.]

Dose guide: Follow product label and start with the lowest effective daily serving..[530,678,902, etc.]

Category: mineral.[530,678,902, etc.]

Safety and Pitfalls

Elevated adverse/interactions signal in literature; review medications and conditions before use.[530,678,902, etc.]
High interaction-signal count detected in literature search.[530,678,902, etc.]
ODS safety note: In some regions of the world, iodine-deficient soils are common, increasing the risk of iodine deficiency among people who consume foods primarily from those areas.[530,678,902, etc.]
ODS safety note: population could be at risk if this trend continued [ 33 ].[530,678,902, etc.]
ODS safety note: Pregnant women who do not consume dairy products may be particularly at risk of iodine insufficiency.[530,678,902, etc.]
ODS safety note: population has adequate iodine intake but that some pregnant women may be at risk for iodine deficiency.[530,678,902, etc.]
ODS safety note: Iodine Deficiency Iodine deficiency has multiple adverse effects on growth and development and is the most common cause of preventable intellectual disability in the world [ 41 ].[530,678,902, etc.]
ODS safety note: Mild to moderate maternal iodine deficiency has also been associated with an increased risk of attention deficit hyperactivity disorder in children [ 44 ].[530,678,902, etc.]
ODS safety note: Chronic iodine deficiency may be associated with an increased risk of the follicular form of thyroid cancer [ 45 ].[530,678,902, etc.]
ODS safety note: Groups at Risk of Iodine Inadequacy Historically, iodine deficiency was endemic in mountainous regions of the United States and Mexico, and in the so called goiter belt around the Great Lakes [ 46 ].[530,678,902, etc.]
ODS interaction note: Food and Drug Administration (FDA) developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet.[530,678,902, etc.]
ODS interaction note: Interactions with Medications Iodine supplements have the potential to interact with several types of medications.[530,678,902, etc.]
ODS interaction note: Individuals taking these medications on a regular basis should discuss their iodine intakes with their health care providers.[530,678,902, etc.]
ODS interaction note: Antithyroid medications Antithyroid medications, such as methimazole (Tapazole), are used to treat hyperthyroidism.[530,678,902, etc.]
Legacy caution group: Hashimoto's without selenium co-supplementation[530,678,902, etc.]
Legacy caution group: Excess can be harmful[530,678,902, etc.]

At-A-Glance Evidence Architecture[2901,3127,3264, etc.]

Clinical Depth

Humans: 4,695 • RCTs: 223 • Meta: 68

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 4,431 • Interactions: 4,700

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

6470 total studies · 4 recent

Timeline

20182024

Top Signal Metrics[2901,3127,3264, etc.]

Animal-only studies

25,884

In vitro / tissue

7,627

Total indexed

6,470

Interaction signals

4,700

Human studies

4,695

Safety adverse signals

4,431

Community Direction Mix[530,678,902, etc.]

Weighted direction score: -20 (Caution Lean)

Benefit1 (33%)

Adverse1 (33%)

No Effect1 (33%)

Mixed0 (0%)

Evidence Quality Summary[2901,3127,3264, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Animal-only studies

25,884

In vitro / tissue

7,627

Total indexed

6,470

Interaction signals

4,700

Human studies

4,695

Safety adverse signals

4,431

Randomized trials

223

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a68

Randomized TrialsLevel 1b223

Human Studies (other)Level 3-44,404

All IndexedAll levels6,470

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[2901,3127,3264, etc.]

PMID 35365361 • 2022 Jun

ESPEN micronutrient guideline.

Clin Nutr

Open PubMed

PMID 38243784 • 2024 Mar

Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Thyroid

Open PubMed

PMID 37811643 • 2024

Health aspects of vegan diets among children and adolescents: a systematic review and meta-analyses.

Crit Rev Food Sci Nutr

Open PubMed

PMID 36154284 • 2022 Oct

Contrast-enhanced Mammography versus Contrast-enhanced Breast MRI: A Systematic Review and Meta-Analysis.

Radiology

Open PubMed

PMID 38206745 • 2023 Dec 29

Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.

Medicine (Baltimore)

Open PubMed

PMID 33336827 • 2020 Dec 18

Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews.

Cochrane Database Syst Rev

Open PubMed

PMID 38652926 • 2024 Mar-Apr

Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: A randomized controlled trial.

Dent Med Probl

Open PubMed

PMID 33650299 • 2021 Jul

Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial.

Clin Transl Sci

Open PubMed

PMID 38051700 • 2023 Dec

Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial.

PLoS Med

Open PubMed

PMID 32272653 • 2020 Apr 7

Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study.

Nutrients

Open PubMed

PMID 30322156 • 2018 Oct 13

Improved Diet Quality and Nutrient Adequacy in Children and Adolescents with Abdominal Obesity after a Lifestyle Intervention.

Nutrients

Open PubMed

PMID 29210520 • 2018 Apr

Supplementation during pregnancy with small-quantity lipid-based nutrient supplements or multiple micronutrients, compared with iron and folic acid, increases women's urinary iodine concentration in semiurban Ghana: A randomized controlled trial.

Matern Child Nutr

Open PubMed

PMID 35010904 • 2021 Dec 23

Nutrient Intake and Status in Adults Consuming Plant-Based Diets Compared to Meat-Eaters: A Systematic Review.

Nutrients

Open PubMed

PMID 30891786 • 2019 Jun

Excess iodine intake: sources, assessment, and effects on thyroid function.

Ann N Y Acad Sci

Open PubMed

PMID 38276540 • 2024 Jan 19

Nutritional Status of Breastfeeding Mothers and Impact of Diet and Dietary Supplementation: A Narrative Review.

Nutrients

Open PubMed

Community Report Frequency[530,678,902, etc.]

Benefit reports: 1

Adverse reports: 1

No-effect reports: 1

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[530,678,902, etc.]

Benefits

Thyroid hormone production: 1
Metabolic regulation: 1
Cognitive development support: 1
Supports breast tissue health: 1

Adverse

Hashimoto's without selenium co-supplementation: 1
Excess can be harmful: 1

No Effect

no noticeable effect: 1

Insufficient empirical signal for a directional adjustment.

Reddit evidence: 0 mentions (confidence 0.00).

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

PerimeterX / captcha block encountered.

Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22iodine%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)

Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22iodine%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)

Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=iodine

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

ODS fact sheet linked for safety review.

Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).

Imported legacy monthly cost signal: ~$7.00.

Legacy community note: Important but somewhat controversial. Health communities emphasize the importance of selenium co-supplementation with iodine. Kelp supplements popular as natural source.

Community Insights[530,678,902, etc.]

Sentiment Score

-0.3/100

Benefit Mentions

No benefit mentions recorded.

Adverse Mentions

No adverse mentions recorded.

Best Responders

No responder profile recorded.

Community Evidence Examples[530,678,902, etc.]

aggregate • unclear

Aggregate community signal: 3 directional mentions (benefit 1, adverse 1, no-effect 1, mixed 0).

Open mention

Retail Signal Examples

amazon

Amazon search for Iodine

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Community Sources

Scientific Evidence Notes[2901,3127,3264, etc.]

1. PubMed evidence summary: Iodine

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 4695, RCTs 223, meta-analyses 68.[2901,3127,3264, etc.]

Open source

2. ESPEN micronutrient guideline.

PUBMED • 2022 • Human evidence curation set

PMID 35365361 from Clin Nutr.