Supplement
Supports broad cellular function with category-specific mechanisms.[1709,2745,3902, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 2 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[503,651,875, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[503,651,875, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 710 • RCTs: 97 • Meta: 3
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 3,383 • Interactions: 8,344
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
2448 total studies · 7 recent
Timeline
Animal-only studies
50,756
Interaction signals
8,344
In vitro / tissue
7,748
Safety adverse signals
3,383
Total indexed
2,448
Human studies
710
Weighted direction score: 0 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
50,756
Interaction signals
8,344
In vitro / tissue
7,748
Safety adverse signals
3,383
Total indexed
2,448
Human studies
710
Randomized trials
97
Meta-analyses
3
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33500553 • 2021 Jul
Vitamin D and schizophrenia: 20 years on.
Mol Psychiatry
Open PubMedPMID 38869961 • 2025 Jul 1
Efficacy of Baclofen as Add-on Therapy for Refractory Gastroesophageal Reflux Disease: A Meta-analysis.
J Clin Gastroenterol
Open PubMedPMID 40913113 • 2025 Dec
Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysis.
Mol Psychiatry
Open PubMedPMID 35851507 • 2022 Nov
High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression.
Hum Psychopharmacol
Open PubMedPMID 38321713 • 2024
GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
J Diet Suppl
Open PubMedPMID 39683592 • 2024 Dec 4
Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study.
Nutrients
Open PubMedPMID 39163908 • 2024 Nov
Gaba-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: A human Double-Blind Placebo-Controlled Cross-Over study.
Brain Behav Immun
Open PubMedPMID 39317299 • 2025 Jan 15
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial.
J Affect Disord
Open PubMedPMID 39180365 • 2024 Dec
High-dose Vitamin-B6 reduces sensory over-responsivity.
J Psychopharmacol
Open PubMedPMID 35508109 • 2022 May 3
Microbiota alterations in proline metabolism impact depression.
Cell Metab
Open PubMedPMID 28164854 • 2017 Mar
The Microbiome-Gut-Brain Axis in Health and Disease.
Gastroenterol Clin North Am
Open PubMedPMID 38350464 • 2023 Nov 27
Bifidobacterium adolescentis - a beneficial microbe.
Benef Microbes
Open PubMedPMID 16971751 • 2006
Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.
Biofactors
Open PubMedPMID 33767348 • 2021 Jul
Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit.
Mol Psychiatry
Open PubMedPMID 35953094 • 2023 Jun
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer.
Gut
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22gaba%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22gaba%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=gaba
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Sentiment Score
-0.3/100
Benefit Mentions
No benefit mentions recorded.
Adverse Mentions
No adverse mentions recorded.
Best Responders
No responder profile recorded.
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Gaba
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 710, RCTs 97, meta-analyses 3.[1709,2745,3902, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33500553 from Mol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 38869961 from J Clin Gastroenterol.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40913113 from Mol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35851507 from Hum Psychopharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38321713 from J Diet Suppl.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39683592 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39163908 from Brain Behav Immun.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39317299 from J Affect Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39180365 from J Psychopharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35508109 from Cell Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28164854 from Gastroenterol Clin North Am.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38350464 from Benef Microbes.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16971751 from Biofactors.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33767348 from Mol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35953094 from Gut.
Outcome: See linked PubMed abstract for methods and outcomes.[1709,2745,3902, etc.]
Open source