Supplement
Supports broad cellular function with category-specific mechanisms.[1623,2077,3051, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
69/100
Moderate depth from human/RCT/meta counts
Community Direction
-15
Caution Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 6 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[43,277,347, etc.]
Dose guide: Human-study daily dose: 45.3 mg-150 mg/day (higher-confidence extraction from PubMed abstracts)..[43,277,347, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 45.3 mg-150 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 39 • RCTs: 4 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 52 • Interactions: 55
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
58 total studies · 1 recent
Timeline
In vitro / tissue
180
Animal-only studies
144
Total indexed
58
Interaction signals
55
Safety adverse signals
52
Human studies
39
Weighted direction score: -15 (Caution Lean)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
In vitro / tissue
180
Animal-only studies
144
Total indexed
58
Interaction signals
55
Safety adverse signals
52
Human studies
39
Randomized trials
4
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 36111381 • 2023
Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women.
Nutr Cancer
Open PubMedPMID 30001982 • 2018 Sep
Comparison of dienogest effects upon 3,3'-diindolylmethane supplementation in models of endometriosis and clinical cases.
Reprod Biol
Open PubMedPMID 15623462 • 2004
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.
Nutr Cancer
Open PubMedPMID 22075942 • 2012 Jan 3
Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial.
Br J Cancer
Open PubMedPMID 39578798 • 2024 Nov 22
Exploring the impact of 3,3'-diindolylmethane on the urinary estrogen profile of premenopausal women.
BMC Complement Med Ther
Open PubMedPMID 36642108 • 2023 Feb 1
Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or Brussels sprouts.
Toxicol Appl Pharmacol
Open PubMedPMID 34035125 • 2021 Aug
3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans.
Drug Metab Dispos
Open PubMedPMID 34273521 • 2022 Oct
Targeting cancer stem cells by nutraceuticals for cancer therapy.
Semin Cancer Biol
Open PubMedPMID 35838143 • 2023 Nov
Natural products derived from medicinal plants and microbes might act as a game-changer in breast cancer: a comprehensive review of preclinical and clinical studies.
Crit Rev Food Sci Nutr
Open PubMedBenefit reports: 2
Adverse reports: 2
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.28
Benefits
Adverse
No Effect
Moderately negative empirical signal; apply a light downgrade.
Reddit evidence: 3 mentions (confidence 0.28) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
ODS fact sheet linked for safety review.
Human-study daily dose signal: 45.3 mg-150 mg/day (confidence HIGH).
Extracted from 4 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$16.00.
Legacy community note: Popular among those managing estrogen dominance, hormonal acne, and men worried about estrogen levels. Women report improved PMS symptoms and clearer skin. Men use it to manage estrogen while on TRT.
Sentiment Score
-0.7099399999999999/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
post • r/Supplements • adverse
DIM (Diindolylmethane) supplement and burning My husband has been taking A DIM (Diindolylmethane) supplement for the past 4 months or so due to side effects from his low T shots. For about that time, I have been having EXTREME burning and …
Open mentionpost • r/Biohackers • adverse
My protocol that has been making me feel superhuman!!!!! I have been experimenting with nearly all herbs and supplements that you could imagine along with all diet trends ect. I'm nearly 40 years old still trying to heal myself more specif…
Open mentionpost • r/Supplements • unclear
I'm being treated for low testosterone and was told to take two new supplements, DHEA plus and DIM plus. These are $75 per month. Can they be found for cheaper? Due to my test results that was discussed today at the low testosterone clinic…
Open mentionpost • r/Supplements • unclear
What can I expect from taking DIM? I (m/44) was concerned about possible hormonal issues, and read up on DIM (diindolylmethane) and its ability to keep testosterone from converting into estrogen. Have any other men used it in the past? Wha…
Open mentionpost • r/Biohackers • benefit
Need input on DIM and libido I (58m) was looking into libido enhancers. Note I’ve been weight lifting for the past couple of decades which includes deadlifts and squats. My lifts haven’t gone down so I’m assuming test levels aren’t an issu…
Open mentionpost • r/Supplements • unclear
Looking for Dim in less than 100mg doses Does anyone know of any Dim supplements (Diindolylmethane) that contain less than 100mg? Most contain 100 or more. Thanks!
Open mentioncomment • r/Biohackers • unclear
More so, it gets rid of the harmful forms of estrogen. That’s why I’m on DIM, too, though a woman.
Open mentioncomment • r/Supplements • unclear
Nothing special about these overpriced supps, DIM and DHEA are widely available.
Open mentioncomment • r/Supplements • unclear
I find 150g of Brocolli (the flower part, not the stalk) or 150g baby Brussel sprouts daily provides a natural form of DIM so much that I don't need to supplement anything. We can't buy DHEA in the UK so I couldn't comment further.
Open mentioncomment • r/Supplements • unclear
Totally reasonable to question the cost, hormone supplements are expensive and you shouldn’t have to overpay if you don’t have to. The key points are: The ingredients themselves (DHEA and DIM) are generally inexpensive in raw form, most of…
Open mentionamazon
Amazon search for Dim
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 39, RCTs 4, meta-analyses 0.[1623,2077,3051, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36111381 from Nutr Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30001982 from Reprod Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2004 • Human evidence curation set
PMID 15623462 from Nutr Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22075942 from Br J Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39578798 from BMC Complement Med Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36642108 from Toxicol Appl Pharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34035125 from Drug Metab Dispos.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34273521 from Semin Cancer Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35838143 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1623,2077,3051, etc.]
Open source