Supplement
Mitochondrial electron transport cofactor with antioxidant activity.[2684,3137,3159, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
27
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 10 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Heart Health, Energy, Longevity.[47,284,360, etc.]
Dose guide: Human-study daily dose: 20 mg-200 mg/day (moderate-confidence extraction from PubMed abstracts)..[47,284,360, etc.]
Category
Cofactor
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 20 mg-200 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 671 • RCTs: 146 • Meta: 51
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 310 • Interactions: 122
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1221 total studies · 3 recent
Timeline
Total indexed
1,221
Animal-only studies
835
Human studies
671
In vitro / tissue
336
Safety adverse signals
310
Randomized trials
146
Weighted direction score: 27 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
1,221
Animal-only studies
835
Human studies
671
In vitro / tissue
336
Safety adverse signals
310
Randomized trials
146
Interaction signals
122
Meta-analyses
51
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39019217 • 2024 Aug
Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
Adv Nutr
Open PubMedPMID 30371340 • 2018 Oct 2
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
J Am Heart Assoc
Open PubMedPMID 39404918 • 2025 Feb
Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.
Neurol Sci
Open PubMedPMID 33402403 • 2021 Jan 5
Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine-a meta-analysis.
BMJ Open
Open PubMedPMID 32851663 • 2020 Aug 27
Antioxidants for female subfertility.
Cochrane Database Syst Rev
Open PubMedPMID 30462179 • 2018 Nov 1
The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Adv Nutr
Open PubMedPMID 34444817 • 2021 Jul 30
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 37686725 • 2023 Aug 23
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Nutrients
Open PubMedPMID 27548886 • 2017 Jan 2
The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study.
Biofactors
Open PubMedPMID 38281937 • 2024 Jan 28
Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.
BMC Cardiovasc Disord
Open PubMedPMID 37159264 • 2023 Jun 8
Randomized crossover clinical trial of coenzyme Q10 and nicotinamide riboside in chronic kidney disease.
JCI Insight
Open PubMedPMID 31241007 • 2021 Apr
The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial.
Nutr Neurosci
Open PubMedPMID 33325173 • 2020 Mar
Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges.
Compr Rev Food Sci Food Saf
Open PubMedPMID 36479481 • 2022 Jun
Dietary supplements for polycystic ovary syndrome.
J Prev Med Hyg
Open PubMedPMID 32933108 • 2020 Sep 13
Disorders of Human Coenzyme Q10 Metabolism: An Overview.
Int J Mol Sci
Open PubMedBenefit reports: 6
Adverse reports: 3
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.39
Benefits
Adverse
No Effect
Ubiquinol often preferred in older adults. | Step2: Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 6 mentions (confidence 0.39) across Biohackers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 20 mg-200 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$25.00.
Legacy community note: Universally recommended, especially for statin users and anyone over 40. Users report improved energy, heart health, and blood pressure improvements. Ubiquinol form strongly preferred for those over 40.
Sentiment Score
0.5640879999999999/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
post • r/Biohackers • unclear
What does your body stop producing with age besides Coq10 which you can supplement with and reverse?
Open mentionpost • r/Supplements • unclear
Should I take Supplement CoQ10 with 20 mg of Rosuvastatin Hello, my latest bloodwork showed high ldl of 198. My doctor immediately started me on 20 mg of rosuvastatin. She also recommended I take the coq10 supplement. Just wanted to see if…
Open mentionpost • r/Supplements • adverse
Coq10/ubiquinol side effects Feel like the flu ish and exhausted and weak. Anyone else get this when they take it?
Open mentionpost • r/Supplements • unclear
Omega 3 with CoQ10 Supplement suggestions. Hey, Could you please suggest good brand of Omega-3 with CoQ10 Supplement ? The NOW brand is costly in India as it is imported from USA.
Open mentionpost • r/Supplements • mixed
Vitamin D and CoQ10 supplements give me terrible angst/anxiety They're some of the most common, universally agreed upon supplements, but they give me terrible angst and anxiety. My Vit D wasn't low, but it was on the low end of the normal …
Open mentionpost • r/Supplements • unclear
Good COq10 supplement Hey guys I already take a decent supplement blend and I'm thinking of adding coq10- I'm a swimmer and I work quite often. I already get vitamin e from another supplement. Any good brand recommendations? Or amount I'm …
Open mentionpost • r/Supplements • benefit
Coq10 nad+ and effects I have some NAD+ but never noticed much effect albeit i only took for a few days. However i am quite sensitive to supplements. Take CoQ10 for example. I take only 30mg and its been 4 days taken in the morning but it …
Open mentioncomment • r/Biohackers • benefit
Everything! As we age, cellular decay means we just are not as efficient at rebuilding anything. Entropy happens. For all body hormones, you must eat adequate cholesterol, which is converted to pregnenalone the starting point for all stero…
Open mentioncomment • r/Biohackers • unclear
CoQ10, NAD+, Collagen, Melatonin, Growth hormone, Sex hormones (testosterone, estrogen), Digestive enzymes, Vitamin D, Aldosterone, Insulin, Antioxidants (e.g. glutathione), Elastin, DHEA, Calcitonin.
Open mentioncomment • r/Supplements • benefit
Yes. My PCP recommended it to me about 10 years ago when I’d started on 20 mg atorvastatin. I recently had reduced to 10 mg atorvastatin but continue to take CoQ10.
Open mentionamazon
Amazon search for CoQ10
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
META_ANALYSIS • 2021 • Adults
Human trial synthesis.
Outcome: Supports symptom burden and select biomarkers.[2684,3137,3159, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 671, RCTs 146, meta-analyses 51.[2684,3137,3159, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39019217 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30371340 from J Am Heart Assoc.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39404918 from Neurol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33402403 from BMJ Open.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32851663 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30462179 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34444817 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37686725 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27548886 from Biofactors.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38281937 from BMC Cardiovasc Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37159264 from JCI Insight.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 31241007 from Nutr Neurosci.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33325173 from Compr Rev Food Sci Food Saf.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36479481 from J Prev Med Hyg.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32933108 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2684,3137,3159, etc.]
Open source