Supplement
Supports broad cellular function with category-specific mechanisms.[3009,3335,3545, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
49
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 7 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[78,197,293, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[78,197,293, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 424 • RCTs: 105 • Meta: 26
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 481 • Interactions: 183
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1008 total studies · 5 recent
Timeline
Animal-only studies
1,481
Total indexed
1,008
In vitro / tissue
502
Safety adverse signals
481
Human studies
424
Interaction signals
183
Weighted direction score: 49 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
1,481
Total indexed
1,008
In vitro / tissue
502
Safety adverse signals
481
Human studies
424
Interaction signals
183
Randomized trials
105
Meta-analyses
26
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39404918 • 2025 Feb
Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.
Neurol Sci
Open PubMedPMID 40431450 • 2025 May 18
The Effect of Dietary Supplements on Male Infertility in Terms of Pregnancy, Live Birth, and Sperm Parameters: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 40134249 • 2024 Dec 27
Alpha Lipoic Acid Supplementation and Iron Homeostasis: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.
Int J Vitam Nutr Res
Open PubMedPMID 31221283 • 2019 Aug
Alpha-lipoic acid (ALA) supplementation effect on glycemic and inflammatory biomarkers: A Systematic Review and meta- analysis.
Clin Nutr ESPEN
Open PubMedPMID 29753588 • 2018 Aug
Effects of alpha-lipoic acid supplementation on C-reactive protein level: A systematic review and meta-analysis of randomized controlled clinical trials.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 32091656 • 2020 Jun
Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials.
Int J Clin Pract
Open PubMedPMID 37686725 • 2023 Aug 23
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Nutrients
Open PubMedPMID 39339645 • 2024 Sep 10
Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy.
Nutrients
Open PubMedPMID 32256955 • 2020
The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
Oxid Med Cell Longev
Open PubMedPMID 39929877 • 2025 Feb 10
Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery.
Sci Rep
Open PubMedPMID 34699040 • 2022 Jan
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
Appl Biochem Biotechnol
Open PubMedPMID 34997178 • 2022 Jan 7
The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines.
Sci Rep
Open PubMedPMID 34970669 • 2022 Aug 1
Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.
Adv Nutr
Open PubMedPMID 35315418 • 2022 Mar 14
Dietary supplements for treatment of endometriosis: A review.
Acta Biomed
Open PubMedPMID 34404247 • 2022 Feb
A systematic review of treatment for patients with burning mouth syndrome.
Cephalalgia
Open PubMedBenefit reports: 5
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.36
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 5 mentions (confidence 0.36) across Biohackers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$18.00.
Legacy community note: Well-respected for blood sugar and neuropathy. R-ALA form gaining preference over racemic ALA. ALCAR + ALA "mito stack" is popular in anti-aging community. Some users report skin improvements.
Sentiment Score
0.7699999999999999/100
Benefit Mentions
Adverse Mentions
No adverse mentions recorded.
Best Responders
No responder profile recorded.
post • r/Biohackers • unclear
Rate my stack Im a student, am teaching math in uni and lifting heavy while using adderall. 29M. Also taking zinc picolinate 15mg a night, 2 mg copper a morning and 1g of nordic natural's dha. I have some other stuff that I dont necessaril…
Open mentionpost • r/Supplements • unclear
What are lesser known supplements that ended up being beneficial for you? I often read in this sub the same handful of supplements that people swear by: Magnesium, zinc, creatine, fish oil, ashwaganda, vitamin D, probiotics, collagen, NAC,…
Open mentionpost • r/Supplements • benefit
How I Am Solving My Nerve Pain After my multiple tests with my neurologist in October, it was determined by her that my likely cause of all my nerve issues was vitamin deficiencies. The good news was that I did not have permanent nerve dam…
Open mentionpost • r/Supplements • benefit
Rate my supplement stack / F35 **Morning Supplements:** **Acetyl-l-carnitine - 500 mg** * **Brand:** Jarrow * **Purpose:** Cognition, mental acuity **Berberine - 500 mg** * **Brand:** Pure Encapsulations * **Purpose:** Blood sugar support …
Open mentionpost • r/Biohackers • benefit
Alternative med stuff I have tried for prostate cancer I am posting this in multiple sites. In short I have developed metastatic prostate cancer and would like to enumerate the complementary medicine stuff I have tried. Please note this ma…
Open mentionpost • r/Biohackers • benefit
Am I taking anti-aging/longevity supplements too far at 22? I’m 22 and I want to preserve my body and looks for as long as possible. Right now, my body is basically at its peak in terms of all these functions, but I don’t want to wait unti…
Open mentionpost • r/Biohackers • benefit
Low Energy & Motivation Despite Adderall + Mitochondrial Stack Hey everyone, Male, late 30s here. I’ve always felt like my baseline energy levels were noticeably lower than my peers—both socially and professionally. About 4 years ago, a do…
Open mentionpost • r/Supplements • unclear
Did the Function Health Tests - Recommended A TON of Supplements Hi. I'm a 40yo woman who has recently been having some heath issues, and can't seem to find a doctor who will listen or do any type of blood panels, outside of a CBC. So, I d…
Open mentionamazon
Amazon search for Alpha-lipoic Acid
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 424, RCTs 105, meta-analyses 26.[3009,3335,3545, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39404918 from Neurol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40431450 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 40134249 from Int J Vitam Nutr Res.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31221283 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29753588 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32091656 from Int J Clin Pract.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37686725 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39339645 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32256955 from Oxid Med Cell Longev.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39929877 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34699040 from Appl Biochem Biotechnol.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34997178 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34970669 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35315418 from Acta Biomed.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34404247 from Cephalalgia.
Outcome: See linked PubMed abstract for methods and outcomes.[3009,3335,3545, etc.]
Open source