Supplement
Choline donor supporting acetylcholine synthesis.[2548,2874,4270, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
57/100
Moderate depth from human/RCT/meta counts
Community Direction
6
Mixed / Neutral • confidence Moderate
Safety Friction
62/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 15 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Focus, Performance.[102,326,371, etc.]
Dose guide: Human-study daily dose: 16.3 mg-600 mg/day (higher-confidence extraction from PubMed abstracts)..[102,326,371, etc.]
Category
Nootropic
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 16.3 mg-600 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 11 • RCTs: 5 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 9 • Interactions: 2
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
16 total studies · 4 recent
Timeline
Animal-only studies
28
Total indexed
16
Human studies
11
In vitro / tissue
10
Safety adverse signals
9
Randomized trials
5
Weighted direction score: 6 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Animal-only studies
28
Total indexed
16
Human studies
11
In vitro / tissue
10
Safety adverse signals
9
Randomized trials
5
Interaction signals
2
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 39683633 • 2024 Dec 9
Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men.
Nutrients
Open PubMedPMID 37229544 • 2023 Dec
Effects of branched chain amino acids, l-citrulline, and alpha-glycerylphosphorylcholine supplementation on exercise performance in trained cyclists: a randomized crossover trial.
J Int Soc Sports Nutr
Open PubMedPMID 29042830 • 2017
Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance.
J Int Soc Sports Nutr
Open PubMedPMID 26582972 • 2015
The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength.
J Int Soc Sports Nutr
Open PubMedPMID 40883125 • 2025 Dec
Lowering plasma S-Adenosylhomocysteine (SAH) in healthy adults with elevated SAH and normal homocysteine using nutritional supplementation.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 34948275 • 2021 Dec 15
The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis.
Int J Mol Sci
Open PubMedPMID 40036805 • 2025 Aug 1
Unlocking the Potential of l-α-Glycerylphosphorylcholine: From Metabolic Pathways to Therapeutic Applications.
Nutr Rev
Open PubMedPMID 39519545 • 2024 Oct 30
Vertical Association Between Dietary Total Choline and L-alpha-glycerylphosphorylcholine and the Cognitive Function in Chinese Adults Aged over 55, Result from China Health and Nutrition Survey 1997-2018.
Nutrients
Open PubMedPMID 34817582 • 2021 Nov 1
Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years.
JAMA Netw Open
Open PubMedBenefit reports: 6
Adverse reports: 3
No-effect reports: 1
Mixed reports: 5
Unclear reports: 0
Signal confidence: 0.41
Benefits
Adverse
No Effect
Often cycled to avoid tolerance. | Step2: Insufficient empirical signal for a directional adjustment.
Reddit evidence: 6 mentions (confidence 0.41) across Supplements, Biohackers, HubermanLab.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 16.3 mg-600 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$20.00.
Legacy community note: Popular in both nootropic and fitness communities. Users appreciate both cognitive and athletic benefits. Some prefer CDP-choline for cognitive purity; Alpha-GPC preferred by athletes for GH and power effects.
Sentiment Score
0.26251199999999997/100
Benefit Mentions
Adverse Mentions
Best Responders
No responder profile recorded.
post • r/Supplements • unclear
Huperzine A + Alpha GPC: experiences and effects?
Open mentionpost • r/Supplements • mixed
I Just started with Piracetam and Alpha GPC yesterday and no noticeable effects yet I took piracetam 800mg 3x a day and alpha GPC 150mg 3x a day yesterday. im a beginner with this, can you recommend a dose or is my dose correct? so far i d…
Open mentionpost • r/Biohackers • mixed
I Just started with Piracetam and Alpha GPC yesterday and no noticeable effects yet I took piracetam 800mg 3x a day and alpha GPC 150mg 3x a day yesterday. im a beginner with this, can you recommend a dose or is my dose correct? so far i d…
Open mentionpost • r/HubermanLab • mixed
Is Alpha-GPC safe to be taken daily for 3 days and does it generally cause any fatigue or side effects after stopping? I have a big exam coming up so I don't have much time to try it out first (I know it's not an ideal time to try a new su…
Open mentionpost • r/Supplements • mixed
Seeking Advice on My Nootropic Stack: Methylene Blue, Noopept, Alpha-GPC, L-Theanine, Ashwagandha, Creatine, Rhodiola Rosea Hey everyone, I’ve been researching nootropics and have put together a stack that I’m considering for cognitive enh…
Open mentionpost • r/Biohackers • mixed
Subject: Seeking Advice on My Nootropic Stack: Methylene Blue, Noopept, Alpha-GPC, L-Theanine, Ashwagandha, Creatine, Rhodiola Rosea Hey everyone, I’ve been researching nootropics and have put together a stack that I’m considering for cogn…
Open mentionpost • r/Biohackers • unclear
Rate my stack Im a student, am teaching math in uni and lifting heavy while using adderall. 29M. Also taking zinc picolinate 15mg a night, 2 mg copper a morning and 1g of nordic natural's dha. I have some other stuff that I dont necessaril…
Open mentionpost • r/Biohackers • benefit
How to biohack brain fog ? Hi everyone, I’m 28 years old and have been struggling with persistent brain fog—slow thinking, trouble focusing, and sometimes even forgetting words mid-sentence. I don’t know what’s causing it, but it feels lik…
Open mentionamazon
Amazon search for Alpha-GPC
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
RCT • 2019 • Adults
Small studies and mixed populations.
Outcome: Possible short-term cognitive and power output support.[2548,2874,4270, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 11, RCTs 5, meta-analyses 0.[2548,2874,4270, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39683633 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37229544 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 29042830 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26582972 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40883125 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34948275 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40036805 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39519545 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34817582 from JAMA Netw Open.
Outcome: See linked PubMed abstract for methods and outcomes.[2548,2874,4270, etc.]
Open source