Habit
Avoid late heavy meals to improve sleep and nocturnal metabolic profile.[1867,1949,2011, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
31/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 0 • links 35
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Classification: add.[1137,1288,1867, etc.]
Best fit: Users with reflux, poor sleep quality, and late-night eating patterns..[1137,1288,1867, etc.]
Goal alignment: Sleep, Metabolic Health, Gut Health, Body Composition.[1137,1288,1867, etc.]
Classification
Add
Evidence Tier
MEDIUM
Best Fit
Users with reflux, poor sleep quality, and late-night eating patterns.
Primary Focus
Sleep, Metabolic Health
Clinical Depth
Humans: 97 • RCTs: 9 • Meta: 1
Cohort / Real-World
Cohort signals: 14
Safety Markers
Adverse signals: 4 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
97 total studies · 9 recent
Timeline
Total indexed
97
Human studies
97
Sleep signals
95
Cardiometabolic signals
45
Neuropsych signals
16
Cohort signals
14
Weighted direction score: 0 (Mixed / Neutral)
High when replicated human meta-analysis/trial/cohort depth is present for the habit or exposure.
Total indexed
97
Human studies
97
Sleep signals
95
Cardiometabolic signals
45
Neuropsych signals
16
Cohort signals
14
Randomized trials
9
Safety adverse signals
4
Meta-analyses
1
Animal-only studies
0
In vitro / tissue
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 32398872 • 2020 Dec
Assessing established BMI variants for a role in nighttime eating behavior in robustly phenotyped Southwestern American Indians.
European journal of clinical nutrition
Open PubMedPMID 36198293 • 2022 Oct 4
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity.
Cell metabolism
Open PubMedPMID 36198291 • 2022 Oct 4
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial.
Benefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Human lifestyle/habit literature
Counts from structured habit/exposure PubMed query set.
Outcome: Humans 49, RCT 2, meta 0, cohort 9, sleep signals 48, cardiometabolic signals 22.[1867,1949,2011, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36198293 from Cell metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Dependency signals
0
Composite of study volume, RCTs, and meta-analyses
Cell metabolism
PMID 40241374 • 2025 Dec
Hypercaloric 16:8 time-restricted eating during 8 weeks of resistance exercise in well-trained men and women.
Journal of the International Society of Sports Nutrition
Open PubMedPMID 40108888 • 2025 Dec
Efficacy of time restricted eating and resistance training on body composition and mood profiles among young adults with overweight/obesity: a randomized controlled trial.
Journal of the International Society of Sports Nutrition
Open PubMedPMID 39226719 • 2024 Oct
Effects of time-restricted eating and low-carbohydrate diet on psychosocial health and appetite in individuals with metabolic syndrome: A secondary analysis of a randomized controlled trial.
Clinical nutrition (Edinburgh, Scotland)
Open PubMedPMID 36252412 • 2022 Dec
Randomized, crossover, open-label study of the relative bioavailability and safety of FT218, a once-nightly sodium oxybate formulation: Phase 1 study in healthy volunteers.
Sleep medicine
Open PubMedPMID 36014925 • 2022 Aug 19
The Effect of Exogenous Melatonin on Eating Habits of Female Night Workers with Excessive Weight.
Nutrients
Open PubMedPMID 32216084 • 2020 Sep
Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy.
Clinical and translational science
Open PubMedPMID 25660340 • 2015 Jun
Education, progressive muscle relaxation therapy, and exercise for the treatment of night eating syndrome. A pilot study.
Appetite
Open PubMedPMID 28715993 • 2017 Aug 21
Metabolic Effects of Intermittent Fasting.
Annual review of nutrition
Open PubMedPMID 29195759 • 2018 Jul
Circadian regulation of glucose, lipid, and energy metabolism in humans.
Metabolism: clinical and experimental
Open PubMedPMID 34550357 • 2022 Mar 9
Time-restricted Eating for the Prevention and Management of Metabolic Diseases.
Endocrine reviews
Open PubMedPMID 36041181 • 2022 Dec 22
Chronotype Differences in Body Composition, Dietary Intake and Eating Behavior Outcomes: A Scoping Systematic Review.
Advances in nutrition (Bethesda, Md.)
Open PubMedPMID 31813824 • 2020 Jan 7
Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome.
Cell metabolism
Open PubMedPMID 32998085 • 2021 Aug
Circadian rhythms and meal timing: impact on energy balance and body weight.
Current opinion in biotechnology
Open PubMedPMID 39287848 • 2024
Misalignment of Circadian Rhythms in Diet-Induced Obesity.
Advances in experimental medicine and biology
Open PubMedPMID 38892035 • 2024 May 28
The Relationship between Circadian Rhythm and Cancer Disease.
International journal of molecular sciences
Open PubMedPMID 38892514 • 2024 May 23
Unfavorable Mealtime, Meal Skipping, and Shiftwork Are Associated with Circadian Syndrome in Adults Participating in NHANES 2005-2016.
Nutrients
Open PubMedPMID 41026251 • 2025 Sep 30
A Narrative Review on Sleep and Eating Behavior.
Current diabetes reports
Open PubMedPMID 28929462 • 2017 Dec
Can body temperature dysregulation explain the co-occurrence between overweight/obesity, sleep impairment, late-night eating, and a sedentary lifestyle?
Eating and weight disorders : EWD
Open PubMedPMID 40131943 • 2025
Time-restricted eating in early-stage Huntington's disease: A 12-week interventional clinical trial protocol.
PloS one
Open PubMedPMID 36403899 • 2023 Jan
The effects of time-restricted eating on sleep, cognitive decline, and Alzheimer's disease.
Experimental gerontology
Open PubMedPMID 40885640 • 2025 Dec
Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study.
Nutrition, metabolism, and cardiovascular diseases : NMCD
Open PubMedCommunity Sources
PUBMED • 2022 • Human evidence curation set
PMID 36014925 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29195759 from Metabolism: clinical and experimental.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32398872 from European journal of clinical nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36198291 from Cell metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40241374 from Journal of the International Society of Sports Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40108888 from Journal of the International Society of Sports Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39226719 from Clinical nutrition (Edinburgh, Scotland).
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36252412 from Sleep medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32216084 from Clinical and translational science.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25660340 from Appetite.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28715993 from Annual review of nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34550357 from Endocrine reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36041181 from Advances in nutrition (Bethesda, Md.).
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31813824 from Cell metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32998085 from Current opinion in biotechnology.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39287848 from Advances in experimental medicine and biology.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38892035 from International journal of molecular sciences.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38892514 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41026251 from Current diabetes reports.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28929462 from Eating and weight disorders : EWD.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40131943 from PloS one.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36403899 from Experimental gerontology.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40885640 from Nutrition, metabolism, and cardiovascular diseases : NMCD.
Outcome: See linked PubMed abstract for methods and outcomes.[1867,1949,2011, etc.]
Open source