Food
Manufactured trans-fat source strongly associated with adverse cardiometabolic outcomes.[1449,1512,1693, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
58/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Classification: limit.[1113,1253,1449, etc.]
Best fit: All users..[1113,1253,1449, etc.]
Goal alignment: Heart Health, Longevity.[1113,1253,1449, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
All users.
Primary Focus
Heart Health, Longevity
Clinical Depth
Humans: 172 • RCTs: 32 • Meta: 4
Cohort / Real-World
Cohort signals: 17
Safety Markers
Adverse signals: 18 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
172 total studies
Timeline
Total indexed
172
Human studies
172
Randomized trials
32
Safety adverse signals
18
Cohort signals
17
Meta-analyses
4
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
172
Human studies
172
Randomized trials
32
Safety adverse signals
18
Cohort signals
17
Meta-analyses
4
In vitro / tissue
2
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 34104953 • 2021 Jun 4
Dietary trans-fatty acid intake in relation to cancer risk: a systematic review and meta-analysis.
Nutr Rev
Open PubMedPMID 25995283 • 2015 Jul
Palm Oil Consumption Increases LDL Cholesterol Compared with Vegetable Oils Low in Saturated Fat in a Meta-Analysis of Clinical Trials.
J Nutr
Open PubMedPMID 19424216 • 2009 May
Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils.
Eur J Clin Nutr
Open PubMedPMID 11592728 • 2001 Aug
Serum cholesterol predictive equations with special emphasis on trans and saturated fatty acids. an analysis from designed controlled studies.
Lipids
Open PubMedPMID 30773586 • 2019 Mar 1
Diets Enriched with Conventional or High-Oleic Acid Canola Oils Lower Atherogenic Lipids and Lipoproteins Compared to a Diet with a Western Fatty Acid Profile in Adults with Central Adiposity.
J Nutr
Open PubMedPMID 33596340 • 2021 May
Consumption of High-Oleic Soybean Oil Improves Lipid and Lipoprotein Profile in Humans Compared to a Palm Oil Blend: A Randomized Controlled Trial.
Lipids
Open PubMedPMID 26561632 • 2015 Dec
Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 20437207 • 2010 May
Effects of partially hydrogenated, semi-saturated, and high oleate vegetable oils on inflammatory markers and lipids.
Lipids
Open PubMedPMID 16825681 • 2006 Jul
Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects.
Am J Clin Nutr
Open PubMedPMID 12540404 • 2003 Feb
Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren.
Am J Clin Nutr
Open PubMedPMID 22583051 • 2012 Jul
Dietary fats and coronary heart disease.
J Intern Med
Open PubMedPMID 36542554 • 2023 Feb 1
Different Types of Industry-Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes: Findings From the NutriNet-Santé Prospective Cohort.
Diabetes Care
Open PubMedPMID 19916363 • 2009 Sep-Oct
Consumption and health effects of trans fatty acids: a review.
J AOAC Int
Open PubMedPMID 18996687 • 2008 Sep-Nov
Trans fatty acids: effects on cardiometabolic health and implications for policy.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 34724806 • 2021 Dec 7
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association.
Circulation
Open PubMedPMID 32738189 • 2020 Aug
Evolution of Trans-fatty acid consumption in Thailand and strategies for its reduction.
J Clin Hypertens (Greenwich)
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22partially%20hydrogenated%20oils%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=partially%20hydrogenated%20oils
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 172, RCT 32, meta 4, cohort 17.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34104953 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25995283 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19424216 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11592728 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30773586 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33596340 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26561632 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20437207 from Lipids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16825681 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 12540404 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22583051 from J Intern Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36542554 from Diabetes Care.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19916363 from J AOAC Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18996687 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34724806 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32738189 from J Clin Hypertens (Greenwich).
Outcome: See linked PubMed abstract for methods and outcomes.[1449,1512,1693, etc.]
Open source