Food
Glucosinolate breakdown products influence antioxidant and detox-related signaling pathways.[1486,1673,2575, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-10
Mixed / Neutral • confidence Moderate
Safety Friction
74/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 7 • links 25
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Classification: prioritize.[169,1190,1486, etc.]
Best fit: People with low vegetable intake and high processed-food exposure..[169,1190,1486, etc.]
Goal alignment: Detox Support, Metabolic Health, Longevity.[169,1190,1486, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
People with low vegetable intake and high processed-food exposure.
Primary Focus
Detox Support, Metabolic Health
Clinical Depth
Humans: 834 • RCTs: 54 • Meta: 38
Cohort / Real-World
Cohort signals: 129
Safety Markers
Adverse signals: 44 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
1056 total studies · 4 recent
Timeline
Total indexed
1,056
Human studies
834
In vitro / tissue
332
Animal-only studies
158
Cohort signals
129
Randomized trials
54
Weighted direction score: -10 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
1,056
Human studies
834
In vitro / tissue
332
Animal-only studies
158
Cohort signals
129
Randomized trials
54
Safety adverse signals
44
Meta-analyses
38
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 28338764 • 2017 Jun 1
Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies.
Int J Epidemiol
Open PubMedPMID 37106252 • 2023 Aug
Fruit and vegetable consumption and the risk of hypertension: a systematic review and meta-analysis of prospective studies.
Eur J Nutr
Open PubMedPMID 26778708 • 2016 Aug
Consumption of citrus and cruciferous vegetables with incident type 2 diabetes mellitus based on a meta-analysis of prospective study.
Prim Care Diabetes
Open PubMedPMID 32086800 • 2020 Aug
The Effects of Cruciferous Vegetable-Enriched Diets on Drug Metabolism: A Systematic Review and Meta-Analysis of Dietary Intervention Trials in Humans.
Clin Pharmacol Ther
Open PubMedPMID 29663679 • 2018 Sep
The Role of Cruciferous Vegetables and Isothiocyanates for Lung Cancer Prevention: Current Status, Challenges, and Future Research Directions.
Mol Nutr Food Res
Open PubMedPMID 29457582 • 2018 May
Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis.
Br J Nutr
Open PubMedPMID 12095953 • 2002 Jun
The Mediet Project.
Ann N Y Acad Sci
Open PubMedPMID 39045769 • 2024 Aug 27
Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis.
Food Funct
Open PubMedPMID 30317146 • 2019 Jan
Broccoli consumption affects the human gastrointestinal microbiota.
J Nutr Biochem
Open PubMedPMID 30661935 • 2019 Apr
Feasibility Outcomes of a Pilot Randomized Clinical Trial to Increase Cruciferous and Green Leafy Vegetable Intake in Posttreatment Head and Neck Cancer Survivors.
J Acad Nutr Diet
Open PubMedPMID 40041932 • 2025 Jun 2
Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer.
Cancer Prev Res (Phila)
Open PubMedPMID 39218859 • 2024 Sep 2
Cruciferous vegetables lower blood pressure in adults with mildly elevated blood pressure in a randomized, controlled, crossover trial: the VEgetableS for vaScular hEaLth (VESSEL) study.
BMC Med
Open PubMedPMID 34767023 • 2021 Nov 1
Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer.
JAMA Netw Open
Open PubMedPMID 16441953 • 2006 Feb
Cruciferous vegetables and colo-rectal cancer.
Proc Nutr Soc
Open PubMedPMID 39078523 • 2024 Oct
Cruciferous vegetables intake reduces pancreatic cancer risk: an updated systematic review with meta-analysis.
Eur J Nutr
Open PubMedPMID 37343525 • 2023
Cruciferous Vegetable Intake and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis.
Urol Int
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 4
Signal confidence: 0.47
Benefits
Adverse
No Effect
Community confidence 0.47 with mentions: benefit 1, adverse 1, no-effect 0.
Subreddit coverage: Biohackers, MealPrepSunday, loseit, vegan.
post • r/MealPrepSunday • unclear
High cruciferous vegetables meal plan Meal 1: Old fashioned oats with shredded cheddar, cream cheese, velveeta slice, water, egg white, salt and pepper, red pepper flakes and smoked paprika. Sautéed baby spinach, green onion, red and orang…
Open mentionpost • r/Biohackers • unclear
IN this study 34 vegetable extracts were tested against 8 different cancer cell lines (lung cancer, kidney cancer, etc). The No. 1 champion cancer fighter was...drum roll....Garlic! Followed by cruciferous vegetables (broc, cabbage, b. spr…
Open mentionpost • r/MealPrepSunday • unclear
Mid week prep(snacks + seasoning combos) *Meal* veggie: snow peas, baby broccoli, cauliflower, gai lan, cremini(slightly heavy on cruciferous vegetables for this batch). protein: grounded turkey base: pearl barley for 🐶: basically the sam…
Open mentionpost • r/vegan • benefit
Nutritional low-thallium equivalents to broccoli and kale So, after some weird symptoms I did a heavy metals test. Thallium was significantly elevated at around 8.5 mcg/g creatinine (range <=0.5). I found out that Brad's kale chips (such a…
Open mentionpost • r/loseit • adverse
Need help figuring this out I am a 43 year old female. 5'2" 186 pounds. I am autistic and have ARFID. I also have IBS, gastritis and diabetes. I was 175 when I was diagnosed with diabetes. My aunt is my caregiver and she put me on a keto d…
Open mentionpost • r/Biohackers • unclear
50% of people in the US and Europe have a medical condition. And an n=1 elimination diet. Disclaimer: no Ai was used or harmed to write this. **TL;DR = just read the passages in bold.** Clinical physiologist Gerald Shulman and his collabor…
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 834, RCT 54, meta 38, cohort 129.[1486,1673,2575, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28338764 from Int J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37106252 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26778708 from Prim Care Diabetes.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32086800 from Clin Pharmacol Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29663679 from Mol Nutr Food Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29457582 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 12095953 from Ann N Y Acad Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39045769 from Food Funct.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30317146 from J Nutr Biochem.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30661935 from J Acad Nutr Diet.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40041932 from Cancer Prev Res (Phila).
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39218859 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34767023 from JAMA Netw Open.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16441953 from Proc Nutr Soc.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39078523 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37343525 from Urol Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1486,1673,2575, etc.]
Open source