Food
Synthetic color additives are under ongoing scrutiny for behavioral and inflammatory endpoints in subsets of users.[2768,3522,3541, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
67/100
Moderate depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
21/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 8 • mentions 0 • links 17
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Classification: limit.[1056,1163,2768, etc.]
Best fit: Users with child behavioral concerns or additive sensitivity patterns..[1056,1163,2768, etc.]
Goal alignment: Cognitive, Mood, Metabolic Health.[1056,1163,2768, etc.]
Classification
Limit
Evidence Tier
MEDIUM
Best Fit
Users with child behavioral concerns or additive sensitivity patterns.
Primary Focus
Cognitive, Mood
Clinical Depth
Humans: 39 • RCTs: 1 • Meta: 1
Cohort / Real-World
Cohort signals: 1
Safety Markers
Adverse signals: 2 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
39 total studies · 1 recent
Timeline
Total indexed
39
Human studies
39
In vitro / tissue
9
Safety adverse signals
2
Randomized trials
1
Meta-analyses
1
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Medium when human evidence exists but is limited, or when non-human evidence volume is substantial.
Total indexed
39
Human studies
39
In vitro / tissue
9
Safety adverse signals
2
Randomized trials
1
Meta-analyses
1
Cohort signals
1
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 32006369 • 2020
Food Color and Autism: A Meta-Analysis.
Adv Neurobiol
Open PubMedPMID 28373021 • 2017 Jul 1
Color of hot soup modulates postprandial satiety, thermal sensation, and body temperature in young women.
Appetite
Open PubMedPMID 32807620 • 2020 Oct
Adverse reactions to food additives in children: A retrospective study and a prospective survey.
Arch Pediatr
Open PubMedPMID 35484553 • 2022 Apr 29
Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence.
Environ Health
Open PubMedPMID 32086499 • 2020 Jun
Early-onset colorectal cancer: initial clues and current views.
Nat Rev Gastroenterol Hepatol
Open PubMedPMID 39129647 • 2024 Oct 10
Allura Red AC is a xenobiotic. Is it also a carcinogen?
Carcinogenesis
Open PubMedPMID 32599104 • 2020 Sep
Certified food dyes in over the counter medicines and supplements marketed for children and pregnant women.
Food Chem Toxicol
Open PubMedPMID 37254351 • 2023 Jul
Consumption of commonly used artificial food dyes increases activity and oxidative stress in the animal model Caenorhabditis elegans.
Food Res Int
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 39, RCT 1, meta 1, cohort 1.[2768,3522,3541, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32006369 from Adv Neurobiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28373021 from Appetite.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32807620 from Arch Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35484553 from Environ Health.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32086499 from Nat Rev Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39129647 from Carcinogenesis.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32599104 from Food Chem Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37254351 from Food Res Int.
Outcome: See linked PubMed abstract for methods and outcomes.[2768,3522,3541, etc.]
Open source