Food
Sulfur compounds from garlic and onion are linked to vascular and immune-relevant signaling.[1390,1487,2572, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Low
Safety Friction
92/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 4 • links 25
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Classification: prioritize.[70,1161,1390, etc.]
Best fit: Users prioritizing cardiometabolic risk reduction..[70,1161,1390, etc.]
Goal alignment: Heart Health, Immune Support, Metabolic Health.[70,1161,1390, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
Users prioritizing cardiometabolic risk reduction.
Primary Focus
Heart Health, Immune Support
Clinical Depth
Humans: 1,197 • RCTs: 104 • Meta: 42
Cohort / Real-World
Cohort signals: 89
Safety Markers
Adverse signals: 108 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1813 total studies · 3 recent
Timeline
Total indexed
1,813
Human studies
1,197
In vitro / tissue
883
Animal-only studies
476
Safety adverse signals
108
Randomized trials
104
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
1,813
Human studies
1,197
In vitro / tissue
883
Animal-only studies
476
Safety adverse signals
108
Randomized trials
104
Cohort signals
89
Meta-analyses
42
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 37033930 • 2023
Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials.
Front Immunol
Open PubMedPMID 39113105 • 2024 Aug 7
Garlic consumption can reduce the risk of dyslipidemia: a meta-analysis of randomized controlled trials.
J Health Popul Nutr
Open PubMedPMID 11010950 • 2000 Oct
Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers.
Am J Clin Nutr
Open PubMedPMID 37481521 • 2023 Jul 22
Effects of garlic supplementation on components of metabolic syndrome: a systematic review, meta-analysis, and meta-regression of randomized controlled trials.
BMC Complement Med Ther
Open PubMedPMID 31895803 • 2020 Jan
Garlic intake and the risk of colorectal cancer: A meta-analysis.
Medicine (Baltimore)
Open PubMedPMID 36571600 • 2023 Apr
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
Eur J Nutr
Open PubMedPMID 39203947 • 2024 Aug 22
LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers.
Nutrients
Open PubMedPMID 35276764 • 2022 Jan 18
Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study.
Nutrients
Open PubMedPMID 40266024 • 2025 Apr 17
Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study.
Aging (Albany NY)
Open PubMedPMID 36789941 • 2023 Jan
Allium vegetable intake associated with the risk of incident gastric cancer: a continuous follow-up study of a randomized intervention trial.
Am J Clin Nutr
Open PubMedPMID 26764332 • 2016 Feb
Aged Garlic Extract Modifies Human Immunity.
J Nutr
Open PubMedPMID 29937536 • 2018 Jun 24
Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods.
Nutrients
Open PubMedPMID 36558386 • 2022 Dec 8
Association between Dietary Patterns and Depression in Chinese Older Adults: A Longitudinal Study Based on CLHLS.
Nutrients
Open PubMedPMID 37118372 • 2022 Mar
Plant-based dietary patterns in relation to mortality among older adults in China.
Nat Aging
Open PubMedPMID 12109342 • 2002 Feb
Chemoprevention of bladder cancer.
Urol Clin North Am
Open PubMedPMID 33054509 • 2021 Aug
Dietary Changes Among Breastfeeding Mothers.
J Hum Lact
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 4
Signal confidence: 0.10
Benefits
Adverse
No Effect
Community confidence 0.10 with mentions: benefit 0, adverse 0, no-effect 0.
Subreddit coverage: Biohackers.
post • r/Biohackers • unclear
IN this study 34 vegetable extracts were tested against 8 different cancer cell lines (lung cancer, kidney cancer, etc). The No. 1 champion cancer fighter was...drum roll....Garlic! Followed by cruciferous vegetables (broc, cabbage, b. spr…
Open mentioncomment • r/Biohackers • unclear
garlic leak onion brus sprouts kale in that order.
Open mentioncomment • r/Biohackers • unclear
Add an extra clove of garlic to everything you cook now. On the other hand, you shouldn't believe that it will replace all the plant diversity that your body needs, the mix is clearly a winner. These studies are crazy how they confirm wh…
Open mentioncomment • r/Biohackers • unclear
>Against Glio. radish and egg plant were no. 1. Against Kidney cancer romaine lettuce and tomato were no. 1 Against breast cancer egg plant, bok choy and carrot were no. 1. The vegetable extracts on the right side of the charts had the hig…
Open mentionEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 1197, RCT 104, meta 42, cohort 89.[1390,1487,2572, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37033930 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39113105 from J Health Popul Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2000 • Human evidence curation set
PMID 11010950 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37481521 from BMC Complement Med Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31895803 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36571600 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39203947 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35276764 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40266024 from Aging (Albany NY).
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36789941 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26764332 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29937536 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36558386 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 37118372 from Nat Aging.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 12109342 from Urol Clin North Am.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33054509 from J Hum Lact.
Outcome: See linked PubMed abstract for methods and outcomes.[1390,1487,2572, etc.]
Open source